States of succinate dehydrogenase in the organism: Dormant vs. hyperactive (pushed out of equilibrium)

Using an original cytobiochemical method to study oxidation in mitochondria, preserving their native network organization within cells in a blood smear, we have revealed a hyperactive state of succinate dehydrogenase that arises in the organism under physiological stress. This is generally consisten...

Full description

Saved in:
Bibliographic Details
Published in:Biophysics (Oxford) 2013, Vol.58 (1), p.86-94
Main Authors: Kondrashova, M. N., Zakharchenko, M. V., Khunderyakova, N. V., Fedotcheva, N. I., Litvinova, E. G., Romanova, O. I., Gulayev, A. A.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biophysics
Complex Systems Biophysics
Equilibrium
Mitochondria
Organisms
Physics
Physics and Astronomy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Using an original cytobiochemical method to study oxidation in mitochondria, preserving their native network organization within cells in a blood smear, we have revealed a hyperactive state of succinate dehydrogenase that arises in the organism under physiological stress. This is generally consistent with the notion of non-equilibrium state of enzymes during their activity. The mechanism moderating the succinate dehydrogenase hyperactivity is based on full-fledged functioning of α-ketoglutarate dehydrogenase, sup-ported by oxidation of isocitrate.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350913010089