Studies of IAA and IBA as fungal [alpha]-amylase inhibitors using enzyme kinetics, molecular modeling and thermodynamics

Simple sugars like glucose and maltose are found to induce the production of aflatoxin. Since the formation of simple sugars is directly linked to [alpha]-amylase function in fungus, it is considered that the inhibition of this enzyme is an effective approach to control the production of aflatoxins....

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Bibliographic Details
Published in:Starch 2012-12, Vol.64 (12), p.991
Main Authors: Dileep, Kalarickal V, Tintu, Ignatius, Remya, Chandran, Haridas, Madathilkovilakathu, Sadasivan, Chittalakkottu
Format: Article
Language:eng ; fre ; ger
Subjects:
Enzyme kinetics
Thermodynamics
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Summary:Simple sugars like glucose and maltose are found to induce the production of aflatoxin. Since the formation of simple sugars is directly linked to [alpha]-amylase function in fungus, it is considered that the inhibition of this enzyme is an effective approach to control the production of aflatoxins. The action of two indole derivatives such as indoleacetic acid (IAA) and indolebutyric acid (IBA) has been investigated by means of enzyme kinetics, isothermal titration calorimetric and molecular docking analysis. The results suggested that both IAA and IBA can inhibit [alpha]-amylase in a competitive manner. [PUBLICATION ABSTRACT]
ISSN:0038-9056
1521-379X
DOI:10.1002/star.201200090