A Catalyst-Free, One-Pot Three-Component Aminomethylation of [alpha]-Substituted Nitroacetates: Theoretical and Experimental Studies into the Rate-Accelerating Effects of the Solvent Methanol

3, 2, 1 go! An unprecedented one-pot, catalyst-free, three-component aminomethylation of α-substituted nitroacetates, formalin, and amines has been reported, thereby enabling the highly efficient synthesis of α,[beta]-diamino acid precursors with great structural diversity.

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2013-05, Vol.8 (5), p.877
Main Authors: Ji, Cong-Bin, Cao, Zhong-Yan, Wang, Xin, Wu, De-Yin, Zhou, Jian
Format: Article
Language:English
Subjects:
Chemistry
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Description
Summary:3, 2, 1 go! An unprecedented one-pot, catalyst-free, three-component aminomethylation of α-substituted nitroacetates, formalin, and amines has been reported, thereby enabling the highly efficient synthesis of α,[beta]-diamino acid precursors with great structural diversity.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201300053