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Antibodies to glutamate reduce the neurotoxic effects of A[beta]^sub 25-35^ in prefrontal cortex cell transcriptome
Alzheimers disease (AD) is a common neurodegenerative disease of elderly persons, one of the key mechanisms in which is the accumulation in the brain parenchyma of aggregated amyloid protein, leading to neuronal death and cognitive impairment. This protein promotes the activation of microglia, trigg...
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Published in: | Doklady. Biochemistry and biophysics 2012-11, Vol.447 (1), p.277 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Alzheimers disease (AD) is a common neurodegenerative disease of elderly persons, one of the key mechanisms in which is the accumulation in the brain parenchyma of aggregated amyloid protein, leading to neuronal death and cognitive impairment. This protein promotes the activation of microglia, triggering of the endosomal lysosomal start signaling system cells, inhibition of tissue oxidation systems, and the development of neurotoxic effects of glutamate. Kolobov et al assessed by molecular genetic methods the effect of intranasal administration of AB Glu on the level of gene expression of the apoptosis inducing factor, proapoptotic caspase 3, and poly(ADP ribose)polymerase 1 in the prefrontal cortex of rats at an early stage of experimental AD. |
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ISSN: | 1607-6729 1608-3091 |
DOI: | 10.1134/S1607672912050092 |