Conservative Therapeutic Approach to Corrosive Poisonings in Adults

Introduction In this study, we assess the effectiveness of a conservative therapeutic treatment of acute corrosive poisonings in adults, and we define therapeutic protocols based on clinical and endoscopic criteria. Methods We analyzed clinical records of patients with acute corrosive poisonings who...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2013-06, Vol.17 (6), p.1044-1049
Main Authors: Chibishev, A., Pereska, Z., Simonovska, N., Chibisheva, V., Glasnovic, M., Chitkushev, L. T.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Antibiotics
Burns, Chemical - therapy
Caustics - poisoning
Endoscopy
Endoscopy, Digestive System
Esophageal Stenosis - chemically induced
Esophageal Stenosis - therapy
Esophagus
Female
Fibrosis - surgery
Gastroenterology
Histamine H2 Antagonists - therapeutic use
Hospitalization
Humans
Injuries
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Parenteral Nutrition, Total
Patients
Performance evaluation
Poisoning
Proton Pump Inhibitors - therapeutic use
Small intestine
Steroids
Stomach - injuries
Stomach - pathology
Stomach - surgery
Suicides & suicide attempts
Surgery
Toxicology
Trauma Severity Indices
Young Adult
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Summary:Introduction In this study, we assess the effectiveness of a conservative therapeutic treatment of acute corrosive poisonings in adults, and we define therapeutic protocols based on clinical and endoscopic criteria. Methods We analyzed clinical records of patients with acute corrosive poisonings who were hospitalized and treated at the Toxicology Clinic at the University of Skopje, Republic of Macedonia, during a 5-year period (2006–2010). A total of 481 patients’ records with cases of acute corrosive poisonings were analyzed. There were 317 female (65.9 %) and 164 male (34.1 %) patients. The purpose of the therapy in the cases of acute corrosive poisonings is to prevent perforation as well as progressive fibrosis and stenosis of the esophagus and stomach. Therapeutic approach mainly consists of proton pump inhibitors, H 2 blockers, antibiotics, and intensive hyperalimentation. There are different opinions regarding conservative treatment of acute corrosive poisonings in adults. Conclusion Based on our study of corrosive poisonings of adults, we propose a list of optimal treatment recommendations.
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-013-2190-9