The role of epistasis in protein evolution/Breen et al. reply

[...]for the three nuclear and chloroplast genes in the Breen et al.6 data set, the average dN/dS values under our non-epistatic model are comparable to or even lower than the empirical dN/dS values Breen and colleagues reported. [...]the dN/dS values observed in these genes need not be attributed t...

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Bibliographic Details
Published in:Nature (London) 2013-05, Vol.497 (7451), p.E1
Main Authors: McCandlish, David M, Rajon, Etienne, Shah, Premal, Ding, Yang, Plotkin, Joshua B, Breen, Michael S, Kemena, Carsten, Vlasov, Peter K, Notredame, Cedric, Kondrashov, Fyodor A
Format: Article
Language:English
Subjects:
Amino acids
Evolution
Genetics
Genomics
Proteins
Online Access:Get full text
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Summary:[...]for the three nuclear and chloroplast genes in the Breen et al.6 data set, the average dN/dS values under our non-epistatic model are comparable to or even lower than the empirical dN/dS values Breen and colleagues reported. [...]the dN/dS values observed in these genes need not be attributed to epistasis, but rather can be explained by the more parsimonious assumption that the various amino acids observed at a site have different fitnesses. [...]sequence divergence is proportional to phylogenetic distance and is usually substantial for sequences from distantly related species.
ISSN:0028-0836
1476-4687