Clozapine-Induced Restless Legs Syndrome Treated With Aripiprazole

Case Report "Ms. M," a 34-year-old woman with a 12-year history of treatment-resistant paranoid schizophrenia, having auditory hallucinations and multiple delusions, had poor response to adequate trials of haloperidol, risperidone, and injection fluphenazine. Because of treatment nonrespon...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2013-04, Vol.25 (2), p.E62-E63
Main Authors: Raveendranathan, Dhanya, Shiva, Lakshmi, Venkatasubramanian, Ganesan, Rao, Mukund G, Varambally, Shivarama, Gangadhar, Bangalore N
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - therapeutic use
Aripiprazole
Clozapine - adverse effects
Dopamine
Drug dosages
Drug therapy
Female
Humans
Piperazines - therapeutic use
Psychotropic drugs
Quinolones - therapeutic use
Restless legs syndrome
Restless Legs Syndrome - drug therapy
Restless Legs Syndrome - etiology
Schizophrenia, Paranoid - complications
Schizophrenia, Paranoid - drug therapy
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Summary:Case Report "Ms. M," a 34-year-old woman with a 12-year history of treatment-resistant paranoid schizophrenia, having auditory hallucinations and multiple delusions, had poor response to adequate trials of haloperidol, risperidone, and injection fluphenazine. Because of treatment nonresponse, she was started on clozapine, which was increased to 200 mg. Aripiprazole also had the added benefit of having a synergistic effect with clozapine,11 which enabled in improvement in the psychotic symptoms and enabled further increase in clozapine dosage, as well. [...]in antipsychotic-induced RLS, aripiprazole could be considered, as it would also have an added antipsychotic effect and, in a case like this, wherein the antipsychotic could not be stopped, as the patient was a nonresponder, and the psychotic symptoms were very severe.
ISSN:0895-0172
1545-7222
DOI:10.1176/appi.neuropsych.12050128