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ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease
Abstract We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagn...
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| Published in: | Modern rheumatology 2013-01, Vol.23 (1), p.156-161 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c2460-a7a07ea5c08eaf5d8b51ff1db70240c0a44480cc539aaf75a6a18cb5ffc06fce3 |
| container_end_page | 161 |
| container_issue | 1 |
| container_start_page | 156 |
| container_title | Modern rheumatology |
| container_volume | 23 |
| creator | Murakami, Masanori Shimane, Kenichi Takahashi, Hiroshi Tomiyama, Junji Nagashima, Masakazu |
| description | Abstract
We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admission to hospital with fervescence, polyarthralgia, purpura, and asymmetric numbness of the extremities. Examination of her genetic background revealed that she carried HLA-DR9, which confers risk of both diseases in Japanese populations. |
| doi_str_mv | 10.3109/s10165-012-0619-8 |
| format | article |
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We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admission to hospital with fervescence, polyarthralgia, purpura, and asymmetric numbness of the extremities. Examination of her genetic background revealed that she carried HLA-DR9, which confers risk of both diseases in Japanese populations.</description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.3109/s10165-012-0619-8</identifier><identifier>PMID: 22391860</identifier><language>eng</language><publisher>United States: Informa Healthcare</publisher><subject>Adult ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - pathology ; Antibodies, Antineutrophil Cytoplasmic - blood ; Antibodies, Antineutrophil Cytoplasmic - immunology ; Azathioprine - therapeutic use ; Cytoplasm ; Drug Therapy, Combination ; Enzymes ; Female ; Genetic Predisposition to Disease ; Genetics ; Glucocorticoids - therapeutic use ; HLA-DR Serological Subtypes - genetics ; Humans ; Immunosuppressive Agents - therapeutic use ; Inflammatory diseases ; Methylprednisolone - therapeutic use ; Mixed Connective Tissue Disease - blood ; Mixed Connective Tissue Disease - complications ; Mixed Connective Tissue Disease - genetics ; Mixed Connective Tissue Disease - pathology ; Myeloblastin - blood ; Myeloblastin - immunology ; Peroxidase - blood ; Peroxidase - immunology ; Polyclonal antibodies ; Prednisolone - therapeutic use ; Pulse Therapy, Drug ; Risk Factors ; Treatment Outcome</subject><ispartof>Modern rheumatology, 2013-01, Vol.23 (1), p.156-161</ispartof><rights>2013 Japan College of Rheumatology 2013</rights><rights>Copyright Springer Science & Business Media Jan 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2460-a7a07ea5c08eaf5d8b51ff1db70240c0a44480cc539aaf75a6a18cb5ffc06fce3</citedby><cites>FETCH-LOGICAL-c2460-a7a07ea5c08eaf5d8b51ff1db70240c0a44480cc539aaf75a6a18cb5ffc06fce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22391860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murakami, Masanori</creatorcontrib><creatorcontrib>Shimane, Kenichi</creatorcontrib><creatorcontrib>Takahashi, Hiroshi</creatorcontrib><creatorcontrib>Tomiyama, Junji</creatorcontrib><creatorcontrib>Nagashima, Masakazu</creatorcontrib><title>ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease</title><title>Modern rheumatology</title><addtitle>Mod Rheumatol</addtitle><description>Abstract
We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admission to hospital with fervescence, polyarthralgia, purpura, and asymmetric numbness of the extremities. Examination of her genetic background revealed that she carried HLA-DR9, which confers risk of both diseases in Japanese populations.</description><subject>Adult</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - pathology</subject><subject>Antibodies, Antineutrophil Cytoplasmic - blood</subject><subject>Antibodies, Antineutrophil Cytoplasmic - immunology</subject><subject>Azathioprine - therapeutic use</subject><subject>Cytoplasm</subject><subject>Drug Therapy, Combination</subject><subject>Enzymes</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Glucocorticoids - therapeutic use</subject><subject>HLA-DR Serological Subtypes - genetics</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Inflammatory diseases</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Mixed Connective Tissue Disease - blood</subject><subject>Mixed Connective Tissue Disease - complications</subject><subject>Mixed Connective Tissue Disease - genetics</subject><subject>Mixed Connective Tissue Disease - pathology</subject><subject>Myeloblastin - blood</subject><subject>Myeloblastin - immunology</subject><subject>Peroxidase - blood</subject><subject>Peroxidase - immunology</subject><subject>Polyclonal antibodies</subject><subject>Prednisolone - therapeutic use</subject><subject>Pulse Therapy, Drug</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><issn>1439-7595</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EglL4ADbIEuvAOIkTW6yqipdUwQbW1tQZq0ZtUuKk0L_HVShiw8oj69w7o8PYhYDrTIC-CQJEIRMQaQKF0Ik6YCORZzopC9CH-1lqecJOQ3gHyKRW-pidpGmmhSpgxBaT5-kkwRAa67Gjim8w2H7pOx_4p-8WvOpxyXcQXzchfm98t-W-5rahLx86qi0N4Mp_xbht6ppsxIjHitATr3wgDHTGjhwuA53_vGP2dn_3On1MZi8PT9PJLLFpXkCCJUJJKC0oQicrNZfCOVHNS0hzsIB5niuwVmYa0ZUSCxTKzqVzFgpnKRuzq6F33TYfPYXOvDd9W8eVRmQlZIUS0cOYiYGybRNCS86sW7_CdmsEmJ1bM7g10a3ZuTUqZi5_mvv5iqrfxF5mBG4HwNeuaVe4IFx2C4st_bnh3_pvFGqJgw</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Murakami, Masanori</creator><creator>Shimane, Kenichi</creator><creator>Takahashi, Hiroshi</creator><creator>Tomiyama, Junji</creator><creator>Nagashima, Masakazu</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201301</creationdate><title>ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease</title><author>Murakami, Masanori ; Shimane, Kenichi ; Takahashi, Hiroshi ; Tomiyama, Junji ; Nagashima, Masakazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2460-a7a07ea5c08eaf5d8b51ff1db70240c0a44480cc539aaf75a6a18cb5ffc06fce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - pathology</topic><topic>Antibodies, Antineutrophil Cytoplasmic - blood</topic><topic>Antibodies, Antineutrophil Cytoplasmic - immunology</topic><topic>Azathioprine - therapeutic use</topic><topic>Cytoplasm</topic><topic>Drug Therapy, Combination</topic><topic>Enzymes</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Glucocorticoids - therapeutic use</topic><topic>HLA-DR Serological Subtypes - genetics</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Inflammatory diseases</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Mixed Connective Tissue Disease - blood</topic><topic>Mixed Connective Tissue Disease - complications</topic><topic>Mixed Connective Tissue Disease - genetics</topic><topic>Mixed Connective Tissue Disease - pathology</topic><topic>Myeloblastin - blood</topic><topic>Myeloblastin - immunology</topic><topic>Peroxidase - blood</topic><topic>Peroxidase - immunology</topic><topic>Polyclonal antibodies</topic><topic>Prednisolone - therapeutic use</topic><topic>Pulse Therapy, Drug</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murakami, Masanori</creatorcontrib><creatorcontrib>Shimane, Kenichi</creatorcontrib><creatorcontrib>Takahashi, Hiroshi</creatorcontrib><creatorcontrib>Tomiyama, Junji</creatorcontrib><creatorcontrib>Nagashima, Masakazu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murakami, Masanori</au><au>Shimane, Kenichi</au><au>Takahashi, Hiroshi</au><au>Tomiyama, Junji</au><au>Nagashima, Masakazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease</atitle><jtitle>Modern rheumatology</jtitle><addtitle>Mod Rheumatol</addtitle><date>2013-01</date><risdate>2013</risdate><volume>23</volume><issue>1</issue><spage>156</spage><epage>161</epage><pages>156-161</pages><issn>1439-7595</issn><eissn>1439-7609</eissn><abstract>Abstract
We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admission to hospital with fervescence, polyarthralgia, purpura, and asymmetric numbness of the extremities. Examination of her genetic background revealed that she carried HLA-DR9, which confers risk of both diseases in Japanese populations.</abstract><cop>United States</cop><pub>Informa Healthcare</pub><pmid>22391860</pmid><doi>10.3109/s10165-012-0619-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Modern rheumatology, 2013-01, Vol.23 (1), p.156-161 |
| issn | 1439-7595 1439-7609 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Adult Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - pathology Antibodies, Antineutrophil Cytoplasmic - blood Antibodies, Antineutrophil Cytoplasmic - immunology Azathioprine - therapeutic use Cytoplasm Drug Therapy, Combination Enzymes Female Genetic Predisposition to Disease Genetics Glucocorticoids - therapeutic use HLA-DR Serological Subtypes - genetics Humans Immunosuppressive Agents - therapeutic use Inflammatory diseases Methylprednisolone - therapeutic use Mixed Connective Tissue Disease - blood Mixed Connective Tissue Disease - complications Mixed Connective Tissue Disease - genetics Mixed Connective Tissue Disease - pathology Myeloblastin - blood Myeloblastin - immunology Peroxidase - blood Peroxidase - immunology Polyclonal antibodies Prednisolone - therapeutic use Pulse Therapy, Drug Risk Factors Treatment Outcome |
| title | ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease |
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