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Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study
Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adole...
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Published in: | Journal of psychoactive drugs 2013-04, Vol.45 (2), p.156-167 |
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description | Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences. |
doi_str_mv | 10.1080/02791072.2013.785837 |
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This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.</description><identifier>ISSN: 0279-1072</identifier><identifier>EISSN: 2159-9777</identifier><identifier>DOI: 10.1080/02791072.2013.785837</identifier><identifier>PMID: 23909003</identifier><identifier>CODEN: JPDRD3</identifier><language>eng</language><publisher>United States: Routledge</publisher><subject>activation ; adolescence ; Adolescent ; Adolescent Behavior ; Age Factors ; anticipation ; Basal Ganglia - physiopathology ; Behavior ; Behavior, Addictive ; Boys ; Brain Mapping - methods ; brain-development ; cannabis ; Case-Control Studies ; Cross-Sectional Studies ; Cues ; Drug use ; fMRI ; Humans ; Hyperactivity ; Iowa ; Magnetic Resonance Imaging ; Male ; Marijuana ; Marijuana Abuse - physiopathology ; Marijuana Abuse - psychology ; Marijuana Smoking - physiopathology ; Marijuana Smoking - psychology ; Motivation ; Netherlands ; nucleus ; Reaction Time ; responsivity ; reward ; reward circuitry ; Sex Factors ; striatum ; Task Performance and Analysis ; Teenagers ; Token Economy ; Young Adult</subject><ispartof>Journal of psychoactive drugs, 2013-04, Vol.45 (2), p.156-167</ispartof><rights>Copyright Taylor & Francis Group, LLC 2013</rights><rights>Copyright Taylor & Francis Ltd. 2013</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3</citedby><cites>FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23909003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jager, Gerry</creatorcontrib><creatorcontrib>Block, Robert I.</creatorcontrib><creatorcontrib>Luijten, Maartje</creatorcontrib><creatorcontrib>Ramsey, Nick F.</creatorcontrib><title>Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study</title><title>Journal of psychoactive drugs</title><addtitle>J Psychoactive Drugs</addtitle><description>Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.</description><subject>activation</subject><subject>adolescence</subject><subject>Adolescent</subject><subject>Adolescent Behavior</subject><subject>Age Factors</subject><subject>anticipation</subject><subject>Basal Ganglia - physiopathology</subject><subject>Behavior</subject><subject>Behavior, Addictive</subject><subject>Boys</subject><subject>Brain Mapping - methods</subject><subject>brain-development</subject><subject>cannabis</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Cues</subject><subject>Drug use</subject><subject>fMRI</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Iowa</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Marijuana</subject><subject>Marijuana Abuse - physiopathology</subject><subject>Marijuana Abuse - psychology</subject><subject>Marijuana Smoking - physiopathology</subject><subject>Marijuana Smoking - psychology</subject><subject>Motivation</subject><subject>Netherlands</subject><subject>nucleus</subject><subject>Reaction Time</subject><subject>responsivity</subject><subject>reward</subject><subject>reward circuitry</subject><subject>Sex Factors</subject><subject>striatum</subject><subject>Task Performance and Analysis</subject><subject>Teenagers</subject><subject>Token Economy</subject><subject>Young Adult</subject><issn>0279-1072</issn><issn>2159-9777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kc1O3DAUha2qqExp36CqLHWd4Tp24oRFq-mIAhKoUoG15ST21ChjT-1kRnn72gog2LC6kn2-c38OQl8ILAlUcAo5rwnwfJkDoUteFRXl79AiJ0Wd1Zzz92iRJFnSHKOPITwAQJmX5Qd0nNMaagC6QNOdsoMczF7h873plG0V1s7j28EbOcgeX0475WUbFWaYsLF41blehTZieC2tlY0J2X0wdoN_uimc4RVeexdCdqsi5Gy0uBn7wSRAeaxv_lxF87GbPqEjLfugPj_WE3T_6_xufZld_764Wq-us7ZgdMhozhnkUDS6YLyWlOiGEM1biAsTrkHpkhSctV3ZMCq7rqw1EM5VTauia8qWnqCz2fcgN8rGOZUVVvrWBOGkEb1pvPSTOIxe2D6V3dgEwVh0LSP8fYbj41Z1aQkve7HzZpugZPD6x5q_YuP2gnJKGS-iwbdHA-_-jSoM4sGNPl4lCEI5AZYDr6KKzao2nc4r_dyBgEhpi6e0RUpbzGlH7OvL6Z6hp3ij4McsMDaGupUH5_tODHLqndde2nQE-maL_-K2vDQ</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Jager, Gerry</creator><creator>Block, Robert I.</creator><creator>Luijten, Maartje</creator><creator>Ramsey, Nick F.</creator><general>Routledge</general><general>Haight Ashbury Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K7.</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope><scope>QVL</scope></search><sort><creationdate>20130401</creationdate><title>Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study</title><author>Jager, Gerry ; Block, Robert I. ; Luijten, Maartje ; Ramsey, Nick F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>activation</topic><topic>adolescence</topic><topic>Adolescent</topic><topic>Adolescent Behavior</topic><topic>Age Factors</topic><topic>anticipation</topic><topic>Basal Ganglia - physiopathology</topic><topic>Behavior</topic><topic>Behavior, Addictive</topic><topic>Boys</topic><topic>Brain Mapping - methods</topic><topic>brain-development</topic><topic>cannabis</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Cues</topic><topic>Drug use</topic><topic>fMRI</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Iowa</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Marijuana</topic><topic>Marijuana Abuse - physiopathology</topic><topic>Marijuana Abuse - psychology</topic><topic>Marijuana Smoking - physiopathology</topic><topic>Marijuana Smoking - psychology</topic><topic>Motivation</topic><topic>Netherlands</topic><topic>nucleus</topic><topic>Reaction Time</topic><topic>responsivity</topic><topic>reward</topic><topic>reward circuitry</topic><topic>Sex Factors</topic><topic>striatum</topic><topic>Task Performance and Analysis</topic><topic>Teenagers</topic><topic>Token Economy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jager, Gerry</creatorcontrib><creatorcontrib>Block, Robert I.</creatorcontrib><creatorcontrib>Luijten, Maartje</creatorcontrib><creatorcontrib>Ramsey, Nick F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><collection>NARCIS:Publications</collection><jtitle>Journal of psychoactive drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jager, Gerry</au><au>Block, Robert I.</au><au>Luijten, Maartje</au><au>Ramsey, Nick F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study</atitle><jtitle>Journal of psychoactive drugs</jtitle><addtitle>J Psychoactive Drugs</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>45</volume><issue>2</issue><spage>156</spage><epage>167</epage><pages>156-167</pages><issn>0279-1072</issn><eissn>2159-9777</eissn><coden>JPDRD3</coden><abstract>Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. 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subjects | activation adolescence Adolescent Adolescent Behavior Age Factors anticipation Basal Ganglia - physiopathology Behavior Behavior, Addictive Boys Brain Mapping - methods brain-development cannabis Case-Control Studies Cross-Sectional Studies Cues Drug use fMRI Humans Hyperactivity Iowa Magnetic Resonance Imaging Male Marijuana Marijuana Abuse - physiopathology Marijuana Abuse - psychology Marijuana Smoking - physiopathology Marijuana Smoking - psychology Motivation Netherlands nucleus Reaction Time responsivity reward reward circuitry Sex Factors striatum Task Performance and Analysis Teenagers Token Economy Young Adult |
title | Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study |
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