Loading…

Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study

Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adole...

Full description

Saved in:
Bibliographic Details
Published in:Journal of psychoactive drugs 2013-04, Vol.45 (2), p.156-167
Main Authors: Jager, Gerry, Block, Robert I., Luijten, Maartje, Ramsey, Nick F.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3
cites cdi_FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3
container_end_page 167
container_issue 2
container_start_page 156
container_title Journal of psychoactive drugs
container_volume 45
creator Jager, Gerry
Block, Robert I.
Luijten, Maartje
Ramsey, Nick F.
description Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.
doi_str_mv 10.1080/02791072.2013.785837
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_1371042078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3004474031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3</originalsourceid><addsrcrecordid>eNp9kc1O3DAUha2qqExp36CqLHWd4Tp24oRFq-mIAhKoUoG15ST21ChjT-1kRnn72gog2LC6kn2-c38OQl8ILAlUcAo5rwnwfJkDoUteFRXl79AiJ0Wd1Zzz92iRJFnSHKOPITwAQJmX5Qd0nNMaagC6QNOdsoMczF7h873plG0V1s7j28EbOcgeX0475WUbFWaYsLF41blehTZieC2tlY0J2X0wdoN_uimc4RVeexdCdqsi5Gy0uBn7wSRAeaxv_lxF87GbPqEjLfugPj_WE3T_6_xufZld_764Wq-us7ZgdMhozhnkUDS6YLyWlOiGEM1biAsTrkHpkhSctV3ZMCq7rqw1EM5VTauia8qWnqCz2fcgN8rGOZUVVvrWBOGkEb1pvPSTOIxe2D6V3dgEwVh0LSP8fYbj41Z1aQkve7HzZpugZPD6x5q_YuP2gnJKGS-iwbdHA-_-jSoM4sGNPl4lCEI5AZYDr6KKzao2nc4r_dyBgEhpi6e0RUpbzGlH7OvL6Z6hp3ij4McsMDaGupUH5_tODHLqndde2nQE-maL_-K2vDQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1371042078</pqid></control><display><type>article</type><title>Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Jager, Gerry ; Block, Robert I. ; Luijten, Maartje ; Ramsey, Nick F.</creator><creatorcontrib>Jager, Gerry ; Block, Robert I. ; Luijten, Maartje ; Ramsey, Nick F.</creatorcontrib><description>Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.</description><identifier>ISSN: 0279-1072</identifier><identifier>EISSN: 2159-9777</identifier><identifier>DOI: 10.1080/02791072.2013.785837</identifier><identifier>PMID: 23909003</identifier><identifier>CODEN: JPDRD3</identifier><language>eng</language><publisher>United States: Routledge</publisher><subject>activation ; adolescence ; Adolescent ; Adolescent Behavior ; Age Factors ; anticipation ; Basal Ganglia - physiopathology ; Behavior ; Behavior, Addictive ; Boys ; Brain Mapping - methods ; brain-development ; cannabis ; Case-Control Studies ; Cross-Sectional Studies ; Cues ; Drug use ; fMRI ; Humans ; Hyperactivity ; Iowa ; Magnetic Resonance Imaging ; Male ; Marijuana ; Marijuana Abuse - physiopathology ; Marijuana Abuse - psychology ; Marijuana Smoking - physiopathology ; Marijuana Smoking - psychology ; Motivation ; Netherlands ; nucleus ; Reaction Time ; responsivity ; reward ; reward circuitry ; Sex Factors ; striatum ; Task Performance and Analysis ; Teenagers ; Token Economy ; Young Adult</subject><ispartof>Journal of psychoactive drugs, 2013-04, Vol.45 (2), p.156-167</ispartof><rights>Copyright Taylor &amp; Francis Group, LLC 2013</rights><rights>Copyright Taylor &amp; Francis Ltd. 2013</rights><rights>Wageningen University &amp; Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3</citedby><cites>FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23909003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jager, Gerry</creatorcontrib><creatorcontrib>Block, Robert I.</creatorcontrib><creatorcontrib>Luijten, Maartje</creatorcontrib><creatorcontrib>Ramsey, Nick F.</creatorcontrib><title>Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study</title><title>Journal of psychoactive drugs</title><addtitle>J Psychoactive Drugs</addtitle><description>Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.</description><subject>activation</subject><subject>adolescence</subject><subject>Adolescent</subject><subject>Adolescent Behavior</subject><subject>Age Factors</subject><subject>anticipation</subject><subject>Basal Ganglia - physiopathology</subject><subject>Behavior</subject><subject>Behavior, Addictive</subject><subject>Boys</subject><subject>Brain Mapping - methods</subject><subject>brain-development</subject><subject>cannabis</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Cues</subject><subject>Drug use</subject><subject>fMRI</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Iowa</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Marijuana</subject><subject>Marijuana Abuse - physiopathology</subject><subject>Marijuana Abuse - psychology</subject><subject>Marijuana Smoking - physiopathology</subject><subject>Marijuana Smoking - psychology</subject><subject>Motivation</subject><subject>Netherlands</subject><subject>nucleus</subject><subject>Reaction Time</subject><subject>responsivity</subject><subject>reward</subject><subject>reward circuitry</subject><subject>Sex Factors</subject><subject>striatum</subject><subject>Task Performance and Analysis</subject><subject>Teenagers</subject><subject>Token Economy</subject><subject>Young Adult</subject><issn>0279-1072</issn><issn>2159-9777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kc1O3DAUha2qqExp36CqLHWd4Tp24oRFq-mIAhKoUoG15ST21ChjT-1kRnn72gog2LC6kn2-c38OQl8ILAlUcAo5rwnwfJkDoUteFRXl79AiJ0Wd1Zzz92iRJFnSHKOPITwAQJmX5Qd0nNMaagC6QNOdsoMczF7h873plG0V1s7j28EbOcgeX0475WUbFWaYsLF41blehTZieC2tlY0J2X0wdoN_uimc4RVeexdCdqsi5Gy0uBn7wSRAeaxv_lxF87GbPqEjLfugPj_WE3T_6_xufZld_764Wq-us7ZgdMhozhnkUDS6YLyWlOiGEM1biAsTrkHpkhSctV3ZMCq7rqw1EM5VTauia8qWnqCz2fcgN8rGOZUVVvrWBOGkEb1pvPSTOIxe2D6V3dgEwVh0LSP8fYbj41Z1aQkve7HzZpugZPD6x5q_YuP2gnJKGS-iwbdHA-_-jSoM4sGNPl4lCEI5AZYDr6KKzao2nc4r_dyBgEhpi6e0RUpbzGlH7OvL6Z6hp3ij4McsMDaGupUH5_tODHLqndde2nQE-maL_-K2vDQ</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Jager, Gerry</creator><creator>Block, Robert I.</creator><creator>Luijten, Maartje</creator><creator>Ramsey, Nick F.</creator><general>Routledge</general><general>Haight Ashbury Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K7.</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope><scope>QVL</scope></search><sort><creationdate>20130401</creationdate><title>Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study</title><author>Jager, Gerry ; Block, Robert I. ; Luijten, Maartje ; Ramsey, Nick F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>activation</topic><topic>adolescence</topic><topic>Adolescent</topic><topic>Adolescent Behavior</topic><topic>Age Factors</topic><topic>anticipation</topic><topic>Basal Ganglia - physiopathology</topic><topic>Behavior</topic><topic>Behavior, Addictive</topic><topic>Boys</topic><topic>Brain Mapping - methods</topic><topic>brain-development</topic><topic>cannabis</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Cues</topic><topic>Drug use</topic><topic>fMRI</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Iowa</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Marijuana</topic><topic>Marijuana Abuse - physiopathology</topic><topic>Marijuana Abuse - psychology</topic><topic>Marijuana Smoking - physiopathology</topic><topic>Marijuana Smoking - psychology</topic><topic>Motivation</topic><topic>Netherlands</topic><topic>nucleus</topic><topic>Reaction Time</topic><topic>responsivity</topic><topic>reward</topic><topic>reward circuitry</topic><topic>Sex Factors</topic><topic>striatum</topic><topic>Task Performance and Analysis</topic><topic>Teenagers</topic><topic>Token Economy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jager, Gerry</creatorcontrib><creatorcontrib>Block, Robert I.</creatorcontrib><creatorcontrib>Luijten, Maartje</creatorcontrib><creatorcontrib>Ramsey, Nick F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>PubMed Central (Full Participant titles)</collection><collection>NARCIS:Publications</collection><jtitle>Journal of psychoactive drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jager, Gerry</au><au>Block, Robert I.</au><au>Luijten, Maartje</au><au>Ramsey, Nick F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study</atitle><jtitle>Journal of psychoactive drugs</jtitle><addtitle>J Psychoactive Drugs</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>45</volume><issue>2</issue><spage>156</spage><epage>167</epage><pages>156-167</pages><issn>0279-1072</issn><eissn>2159-9777</eissn><coden>JPDRD3</coden><abstract>Adolescents' risk-taking behavior has been linked to a maturational imbalance between reward ("go") and inhibitory-control ("stop")-related brain circuitry. This may drive adolescent drug-taking, such as cannabis use. In this study, we assessed the non-acute effects of adolescent cannabis use on reward-related brain function. We performed a two-site (United States and Netherlands; pooled data) functional magnetic resonance imaging (fMRI) study with a cross-sectional design. Twenty-one abstinent but frequent cannabis-using boys were compared with 24 non-using peers on reward-related brain function, using a monetary incentive delay task with fMRI. Focus was on anticipatory and response stages of reward and brain areas critically involved in reward processing like the striatum. Performance in users was normal. Region-of-interest analysis indicated striatal hyperactivity during anticipatory stages of reward in users. Intriguingly, this effect was most pronounced during non-rewarding events. Striatal hyperactivity in adolescent cannabis users may signify an overly sensitive motivational brain circuitry. Frequent cannabis use during adolescence may induce diminished ability to disengage the motivational circuit when no reward can be obtained. This could strengthen the search for reinforcements like drugs of abuse, even when facing the negative (non-rewarding) consequences.</abstract><cop>United States</cop><pub>Routledge</pub><pmid>23909003</pmid><doi>10.1080/02791072.2013.785837</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0279-1072
ispartof Journal of psychoactive drugs, 2013-04, Vol.45 (2), p.156-167
issn 0279-1072
2159-9777
language eng
recordid cdi_proquest_journals_1371042078
source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects activation
adolescence
Adolescent
Adolescent Behavior
Age Factors
anticipation
Basal Ganglia - physiopathology
Behavior
Behavior, Addictive
Boys
Brain Mapping - methods
brain-development
cannabis
Case-Control Studies
Cross-Sectional Studies
Cues
Drug use
fMRI
Humans
Hyperactivity
Iowa
Magnetic Resonance Imaging
Male
Marijuana
Marijuana Abuse - physiopathology
Marijuana Abuse - psychology
Marijuana Smoking - physiopathology
Marijuana Smoking - psychology
Motivation
Netherlands
nucleus
Reaction Time
responsivity
reward
reward circuitry
Sex Factors
striatum
Task Performance and Analysis
Teenagers
Token Economy
Young Adult
title Tentative Evidence for Striatal Hyperactivity in Adolescent Cannabis-Using Boys: A Cross-Sectional Multicenter fMRI Study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T10%3A36%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tentative%20Evidence%20for%20Striatal%20Hyperactivity%20in%20Adolescent%20Cannabis-Using%20Boys:%20A%20Cross-Sectional%20Multicenter%20fMRI%20Study&rft.jtitle=Journal%20of%20psychoactive%20drugs&rft.au=Jager,%20Gerry&rft.date=2013-04-01&rft.volume=45&rft.issue=2&rft.spage=156&rft.epage=167&rft.pages=156-167&rft.issn=0279-1072&rft.eissn=2159-9777&rft.coden=JPDRD3&rft_id=info:doi/10.1080/02791072.2013.785837&rft_dat=%3Cproquest_pubme%3E3004474031%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c543t-32740205bf5479a31fb11f7c085817f0ef61574cd6b43add69f0177e9385db6c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1371042078&rft_id=info:pmid/23909003&rfr_iscdi=true