Diagnostic performance of ^sup 18^F-fluorothymidine PET/CT for primary colorectal cancer and its lymph node metastasis: comparison with ^sup 18^F-fluorodeoxyglucose PET/CT

To examine the diagnostic performance of ^sup 18^F-fluorothymidine (FLT) PET/CT in primary and metastatic lymph node colorectal cancer foci in comparison with ^sup 18^F-fluorodeoxyglucose (FDG) PET/CT. The study population comprised 28 patients with 30 newly diagnosed colorectal cancers who underwen...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2013-08, Vol.40 (8), p.1223
Main Authors: Nakajo, Masatoyo, Nakajo, Masayuki, Kajiya, Yoriko, Jinguji, Megumi, Nishimata, Nobuaki, Shimaoka, Shunji, Nihara, Tohru, Aridome, Kuniaki, Tanaka, Sadao, Fukukura, Yoshihiko, Tani, Atushi, Koriyama, Chihaya
Format: Article
Language:English
Subjects:
Colorectal cancer
Comparative studies
Diagnostics
Drug therapy
Metastasis
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Summary:To examine the diagnostic performance of ^sup 18^F-fluorothymidine (FLT) PET/CT in primary and metastatic lymph node colorectal cancer foci in comparison with ^sup 18^F-fluorodeoxyglucose (FDG) PET/CT. The study population comprised 28 patients with 30 newly diagnosed colorectal cancers who underwent surgical resection of the primary lesion and regional lymph nodes after both FLT and FDG PET/CT. The associations between SUVmax levels and pathological factors were evaluated using the Mann-Whitney U or Kruskal-Wallis test. Differences in diagnostic indexes for detecting nodal metastasis between the two tracers were estimated using the McNemar exact or [chi] ^sup 2^ test. All 30 primary cancers (43.0±20.0 mm, range 14 - 85 mm) were visualized by both tracers, but none of the FLT SUVmax values exceeded the FDG SUVmax values in any of the primary cancers (6.6±2.4 vs. 13.6±5.8, p
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-013-2424-9