CH Functionalization Logic Enables Synthesis of (+)-HongoquercinA and Related Compounds

The specifics: A synthesis of the sesquiterpenoid antibiotic (+)-hongoquercinA using sequential site-specific CH methylation and oxidation reactions is described. A key advancement toward this goal was the development of a ligand-accelerated CH methylation reaction, and enabled the generation of a l...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-07, Vol.52 (28), p.7317
Main Authors: Rosen, Brandon R, Simke, Leah R, Thuy-Boun, Peter S, Dixon, Darryl D, Yu, Jin-Quan, Baran, Phil S
Format: Article
Language:English
Online Access:Get full text
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Summary:The specifics: A synthesis of the sesquiterpenoid antibiotic (+)-hongoquercinA using sequential site-specific CH methylation and oxidation reactions is described. A key advancement toward this goal was the development of a ligand-accelerated CH methylation reaction, and enabled the generation of a library of eight structurally diverse analogues.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201303838