Antiproliferative Efficacy of Hesperetin (Citrus Flavanoid) in 1,2-Dimethylhydrazine-Induced Colon Cancer

Cancer is the second leading cause of death worldwide and is increasing at an alarming rate. The present study was to evaluate the antiproliferative effcts of hesperetin, a flavonoid commonly found in many herbal medicines and foods, on aberrant crypt foci (ACF), argyrophylic nucleolar organizer reg...

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Bibliographic Details
Published in:Phytotherapy research 2013-07, Vol.27 (7), p.999-1005
Main Authors: Aranganathan, Selvaraj, Nalini, Namasivayam
Format: Article
Language:English
Subjects:
1,2-Dimethylhydrazine
aberrant crypt foci
Aberrant Crypt Foci - chemically induced
Aberrant Crypt Foci - drug therapy
AgNORs
Animals
Anticarcinogenic Agents - therapeutic use
antiproliferation
Carcinogens
Cell Transformation, Neoplastic - chemically induced
Cell Transformation, Neoplastic - drug effects
colon cancer
Colonic Neoplasms - chemically induced
Colonic Neoplasms - prevention & control
hesperetin
Hesperidin - therapeutic use
Male
Nucleolus Organizer Region - drug effects
Nucleolus Organizer Region - pathology
PCNA
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Proliferating Cell Nuclear Antigen - drug effects
Rats
Rats, Wistar
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Summary:Cancer is the second leading cause of death worldwide and is increasing at an alarming rate. The present study was to evaluate the antiproliferative effcts of hesperetin, a flavonoid commonly found in many herbal medicines and foods, on aberrant crypt foci (ACF), argyrophylic nucleolar organizer regions (AgNORs) and proliferating cell nuclear antigen (PCNA) in 1,2‐dimethylhydrazine (DMH)‐induced colon carcinogenesis in rats. Rats were given subcutaneous injections of DMH (20 mg/kg body weight) weekly for 15 weeks to induce carcinogenesis, and hesperetin was administered orally at the dose of 20 mg/kg body weight. DMH exposure alone produced a high incidence of ACF and showed positive staining for PCNA and AgNORs in colonic tissues. Supplementation with hesperetin lowered the PCNA labeling index and suppressed the formation of ACF in the rats with colon cancer. These results clearly reveal that dietary hesperetin possesses antiproliferative ability against chemically induced colon tumourigenesis. Copyright © 2012 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.4826