Expression of cyclin A, cyclin E and p27 in normal, hyperplastic and frankly malignant endometrial samples

Cellular growth is under the control of certain molecules such as cyclins and cyclin dependent kinases. Dysregulation of these proteins disrupt cell cycle and may trigger malignant transformation. Cyclins and kinase inhibitors also play essential roles in endometrial cellular proliferation. But the...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2013-07, Vol.33 (5), p.508-511
Main Authors: Gezginc, S. T., Celik, C., Dogan, N. U., Toy, H., Tazegul, A., Colakoglu, M. C.
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma - metabolism
Case-Control Studies
Cyclin A
Cyclin A - metabolism
cyclin E
Cyclin E - metabolism
Cyclin-Dependent Kinase Inhibitor p27 - metabolism
Endometrial cancer
endometrial hyperplasia
Endometrial Hyperplasia - metabolism
Endometrial Neoplasms - metabolism
Female
Gynecology
Humans
Middle Aged
proliferative endometrium
Proteins
Reproductive system
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Summary:Cellular growth is under the control of certain molecules such as cyclins and cyclin dependent kinases. Dysregulation of these proteins disrupt cell cycle and may trigger malignant transformation. Cyclins and kinase inhibitors also play essential roles in endometrial cellular proliferation. But the exact roles of these mediators in the disease process is not clear. We evaluated expression of cyclin A, cyclin E and p27 in normal, hyperplastic and malignant endometrial samples assuming different expression patterns in physiological and pathological processes. A total of 75 patients with histopathological diagnosis of normal proliferative, hyperplastic or malignant endometrial samples were evaluated with different cellular proliferation markers, cyclin A, cyclin E and p27. For cyclin E, endometrial cancer samples had higher rate of immunoreactivity than normal proliferative and hyperplastic endometrial samples. Staining properties for cyclin A were comparable for three groups. However, p27 immunoreactivity decreased progressively as lesions progress from proliferative benign endometrium to frank carcinoma. Further large-scale studies with clinical follow-up will reveal the exact role of cyclins on endometrial carcinogenesis.
ISSN:0144-3615
1364-6893
DOI:10.3109/01443615.2013.776024