Anti-Infl ammatory Activity of TS-13, ARE-Inducing Phenol Antioxidant

The protective effect of water-soluble TS-13 monophenol inducing the antioxidant-responsive element (ARE) system was studied on the models of acute inflammation. Intragastric administration of TS-13 to rats significantly reduced the severity of acute aseptic inflammation induced by intravenous injec...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-07, Vol.155 (3), p.366-369
Main Authors: Menshchikova, E. B., Tkachev, V. O., Zenkov, N. K., Lemza, A. E., Sharkova, T. V., Kandalintseva, N. V.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Pathology
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Summary:The protective effect of water-soluble TS-13 monophenol inducing the antioxidant-responsive element (ARE) system was studied on the models of acute inflammation. Intragastric administration of TS-13 to rats significantly reduced the severity of acute aseptic inflammation induced by intravenous injection of zymosan particles: granulocyte blood count and volume density of infiltrates in the liver decreased on day 3, spontaneous production of activated oxygen metabolites and respiratory burst in blood granulocytes decreased on days 2 and 3. A single dose of TS-13 improved survival of mice with endotoxin shock induced by intraperitoneal injection of E. coli LPS. These results confirmed high anti-inflammatory activity of TS-13.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2155-8