Antifungal Activities of Diphenyl Diselenide alone and in Combination with Fluconazole or Amphotericin B against Candidaglabrata

Here, we evaluated combinations of diphenyl diselenide [(PhSe) 2 ] with fluconazole and amphotericin B in a checkerboard assay against clinical Candida glabrata strains. Minimal inhibitory concentration (geometric mean) ranged from 0.25 to >64 (5.16 μg/mL) for (PhSe) 2 , 1 to 32 (5.04 μg/mL) for...

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Bibliographic Details
Published in:Mycopathologia (1975) 2013-08, Vol.176 (1-2), p.165-169
Main Authors: Denardi, Laura Bedin, Mario, Débora Alves Nunes, de Loreto, Érico Silva, Nogueira, Cristina Wayne, Santurio, Janio Morais, Alves, Sydney Hartz
Format: Article
Language:English
Subjects:
Antimicrobial agents
Biomedical and Life Sciences
Drug interactions
Eukaryotic Microbiology
Infections
Life Sciences
Medical Microbiology
Microbial Ecology
Microbiology
NMR
Nuclear magnetic resonance
Plant Sciences
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Summary:Here, we evaluated combinations of diphenyl diselenide [(PhSe) 2 ] with fluconazole and amphotericin B in a checkerboard assay against clinical Candida glabrata strains. Minimal inhibitory concentration (geometric mean) ranged from 0.25 to >64 (5.16 μg/mL) for (PhSe) 2 , 1 to 32 (5.04 μg/mL) for fluconazole and 0.06 to 0.5 (0.18 μg/mL) for amphotericin B. Synergistic (76.66 %) and indifferent (23.34 %) interactions were observed for (PhSe) 2  + amphotericin B combination. (PhSe) 2  + fluconazole combination demonstrated indifferent (50 %) and antagonistic (40 %) interactions, whereas synergistic interactions were observed in 10 % of the isolates. New experimental in vivo protocols are necessary and will promote a better understanding of the antimicrobial activity of (PhSe) 2 against C. glabrata and its use as an adjuvant therapy with antifungal agents.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-013-9672-x