The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium

The insulin-like growth factor-1 receptor (IGF-1R), like the insulin receptor (IR), plays a significant role in determining bioavailability of the critical signalling molecule nitric oxide (NO) and hence, modulates endothelial cell function, particularly in response to stimulation with insulin. In p...

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Bibliographic Details
Published in:Pflügers Archiv 2013-08, Vol.465 (8), p.1065-1074
Main Authors: Gatenby, V. Kate, Imrie, Helen, Kearney, Mark
Format: Article
Language:English
Subjects:
Animals
Biological Availability
Biomedical and Life Sciences
Biomedicine
Cell Biology
Endothelial Cells - metabolism
Endothelial Cells - physiology
Endothelium - metabolism
Endothelium - physiology
Human Physiology
Humans
Insulin - metabolism
Invited Review
Molecular Medicine
Neurosciences
Nitric Oxide - metabolism
Receptor, IGF Type 1 - metabolism
Receptors
Signal Transduction - physiology
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Summary:The insulin-like growth factor-1 receptor (IGF-1R), like the insulin receptor (IR), plays a significant role in determining bioavailability of the critical signalling molecule nitric oxide (NO) and hence, modulates endothelial cell function, particularly in response to stimulation with insulin. In particular, the ability of the IGF-1R to form hybrid receptors with the IR appears to be highly significant in determining the sensitivity of the endothelial cell to insulin. This review will examine the structure of the IGF-1R and how this, with particular reference to the ability of the IGF-1R and the IR to form hybrid receptors, may have an effect both on endothelial cell function and the development of cardiovascular disease.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-013-1218-z