Signal Transducer and Activator of Transcription Factor 6 Signaling Contributes to Control Host Lung Pathology but Favors Susceptibility against Toxocara canisInfection

Using STAT[superscript] 6 - / -[/superscript] BALB/c mice, we have analyzed the role of STAT6-induced Th2 response in determining the outcome of experimental toxocariasis caused by embryonated eggs of the helminth parasite Toxocara canis. Following T. canisinfection wild-type BALB/c mice developed a...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013
Main Authors: Faz-López, Berenice, Ledesma-Soto, Yadira, Romero-Sánchez, Yolanda, Calleja, Elsa, Martínez-Labat, Pablo, Terrazas, Luis I
Format: Article
Language:English
Subjects:
Laboratory animals
Lungs
Parasites
Pathology
Rodents
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Summary:Using STAT[superscript] 6 - / -[/superscript] BALB/c mice, we have analyzed the role of STAT6-induced Th2 response in determining the outcome of experimental toxocariasis caused by embryonated eggs of the helminth parasite Toxocara canis. Following T. canisinfection wild-type BALB/c mice developed a strong Th2-like response, produced high levels of IgG1, IgE, and IL-4, recruited alternatively activated macrophages, and displayed a moderate pathology in the lungs; however, they harbored heavy parasite loads in different tissues. In contrast, similarly infected STAT[superscript] 6 - / -[/superscript] BALB/c mice mounted a weak Th2-like response, did not recruit alternatively activated macrophages, displayed a severe pathology in the lungs, but efficiently controlled T. canisinfection. These findings demonstrate that Th2-like response induced via STAT6-mediated signaling pathway mediates susceptibility to larval stage of T. canis. Furthermore, they also indicate that unlike most gastrointestinal helminths, immunity against larvae of T. canisis not mediated by a Th2-dominant response.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/696343