HAWTHORN (CRATAEGUS OXYCANTHA) BERRIES LOWERS ELEVATED SERUM LIPIDS IN LAB ANIMALS

The purpose of this present study was to investigate the antihyperlipidemic effect of Hawthorn berries (Crataegus oxycantha) after oral administration of crude extract in lab animals, as well as to report the chemical analysis findings relating to major bioactive compounds flavonoids and procyanidin...

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Published in:FUUAST jounral of biology 2012-12, Vol.2 (2), p.79
Main Authors: Sualeh, Mohammad, Baig, Mirza Tasawer, Mahmood, Zafar Alam, Mahmood, Saad Bin Zafar, Khan, Khalid
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Baig, Mirza Tasawer
Mahmood, Zafar Alam
Mahmood, Saad Bin Zafar
Khan, Khalid
description The purpose of this present study was to investigate the antihyperlipidemic effect of Hawthorn berries (Crataegus oxycantha) after oral administration of crude extract in lab animals, as well as to report the chemical analysis findings relating to major bioactive compounds flavonoids and procyanidins present in the species of Crataegus oxycantha available in Pakistan. Albino rabbits were made hyperlipidemic by feeding an atherogenic diet formulation. The antihyperlipidemic test was carried out at one dose level, 100 mg/kg body weight. Blood samples were obtained from the animals of both groups before starting the experiment for initial value, after feeding atherogenic diet for 30 days and then at 20, 40 and 60 days of the treatment. Promising antihyperlipidemic effect of Hawthorn berries was observed in lab animals. Significant reduction was noted in triglyceride, up to 57.75%, total cholesterol, (71.33%) and LDL (84.03%), as compared to, while no difference recorded in the HDL profile between test and control group. All twelve subjects completed the study. No mortality was observed.
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Albino rabbits were made hyperlipidemic by feeding an atherogenic diet formulation. The antihyperlipidemic test was carried out at one dose level, 100 mg/kg body weight. Blood samples were obtained from the animals of both groups before starting the experiment for initial value, after feeding atherogenic diet for 30 days and then at 20, 40 and 60 days of the treatment. Promising antihyperlipidemic effect of Hawthorn berries was observed in lab animals. Significant reduction was noted in triglyceride, up to 57.75%, total cholesterol, (71.33%) and LDL (84.03%), as compared to, while no difference recorded in the HDL profile between test and control group. All twelve subjects completed the study. 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title HAWTHORN (CRATAEGUS OXYCANTHA) BERRIES LOWERS ELEVATED SERUM LIPIDS IN LAB ANIMALS
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