Potential anti-angiogenic sulfates of andrographolide

A new regioisomer of andrographolide, 17-hydro-9-dehydro-andrographolide (1), and five new sulfates of andrographolide (2–6) were isolated from Xiyanping, a China licensed anti-inflammatory drug derived from andrographolide through sulfation reaction. Their chemical structures were elucidated by spe...

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Bibliographic Details
Published in:Journal of asian natural products research 2013-08, Vol.15 (8), p.809-818
Main Authors: Xiao, Xiao-Wu, Fu, Hui-Zheng, Luo, Yue-Hua, Wei, Xiao-Yi
Format: Article
Language:English
Subjects:
andrographolide
Angiogenesis
Angiogenesis Inhibitors - chemistry
Angiogenesis Inhibitors - pharmacology
Animals
anti-angiogenesis
anti-inflammatory agents
aorta
Aorta - drug effects
Cell Movement - drug effects
chemical structure
Diterpenes - chemistry
Diterpenes - pharmacology
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
endothelial cells
Endothelial Cells - drug effects
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Rats
spectroscopy
Stereoisomerism
sulfates
sulfates of andrographolide
Sulfuric Acid Esters - chemistry
Sulfuric Acid Esters - pharmacology
Xiyanping
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Summary:A new regioisomer of andrographolide, 17-hydro-9-dehydro-andrographolide (1), and five new sulfates of andrographolide (2–6) were isolated from Xiyanping, a China licensed anti-inflammatory drug derived from andrographolide through sulfation reaction. Their chemical structures were elucidated by spectroscopic and chemical methods. The inhibition effects of these compounds on angiogenesis were evaluated by rat aortic ring assay. Compounds 1 and 3 exhibited strong inhibitory activities on vascular endothelial cell tube formation in rat aorta ring at the concentration of 1 μM. Compounds 4 and 5 showed moderate suppression on angiogenesis at 10 μM.
ISSN:1477-2213
1028-6020
1477-2213
DOI:10.1080/10286020.2013.803473