Five-year follow-up study of a kidney-tonifying herbal Fufang for prevention of postmenopausal osteoporosis and fragility fractures

To observe the kidney-tonifying herbal Fufangs with phytoestrogenic epimedium for prevention of postmenopausal osteoporosis with both bone mineral density (BMD) and fracture as study endpoints, a 5-year multicenter follow-up study in 194 postmenopausal women (47–70 years old) was conducted in which...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2012-09, Vol.30 (5), p.517-524
Main Authors: Deng, Wei-min, Zhang, Peng, Huang, Hai, Shen, You-gao, Yang, Qin-hua, Cui, Wei-li, He, Yang-shu, Wei, Song, Ye, Zhu, Liu, Fang, Qin, Ling
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Bone Density - drug effects
Bone Resorption - drug therapy
Bone Resorption - prevention & control
Calcium - administration & dosage
Dietary Supplements
Diseases of the osteoarticular system
Drugs, Chinese Herbal - adverse effects
Drugs, Chinese Herbal - therapeutic use
Epimedium
Female
Follow-Up Studies
Fractures, Bone - drug therapy
Fractures, Bone - prevention & control
Humans
Injuries of the limb. Injuries of the spine
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
Orthopedics
Osteoporosis, Postmenopausal - drug therapy
Osteoporosis, Postmenopausal - prevention & control
Osteoporosis. Osteomalacia. Paget disease
Phytotherapy - methods
Plant Preparations - adverse effects
Plant Preparations - therapeutic use
Traumas. Diseases due to physical agents
Vitamin D - administration & dosage
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Summary:To observe the kidney-tonifying herbal Fufangs with phytoestrogenic epimedium for prevention of postmenopausal osteoporosis with both bone mineral density (BMD) and fracture as study endpoints, a 5-year multicenter follow-up study in 194 postmenopausal women (47–70 years old) was conducted in which the subjects were given oral administration of herbal Fufang (10 g/day, twice per day, n  = 101) or placebo ( n  = 93). Both groups were supplemented daily with calcium (600 mg) and vitamin D (400 IU). BMD at distal radius, potential adverse events, and fracture incidence were evaluated at baseline and at 6, 12, 24, 36, 48, and 60 months. At the end of 5 years, 155 subjects had completed the study, with better adherence in the treatment group (13% dropouts, n  = 88 at year 5) as compared with the control group (28% dropouts, n  = 67 at year 5) ( P  
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-012-0351-7