Locoregional Recurrence Following Accelerated Partial Breast Irradiation for Early-Stage Invasive Breast Cancer: Significance of Estrogen Receptor Status and Other Pathological Variables

Background Understanding risk factors for locoregional recurrence (LRR) after accelerated partial breast irradiation (APBI) can help to guide patient selection for treatment with APBI. Published findings to date have not been consistent. More data are needed as these risk factors continue to be defi...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 2013-10, Vol.20 (11), p.3446-3452
Main Authors: Cannon, Donald M., McHaffie, Derek R., Patel, Rakesh R., Adkison, Jarrod B., Das, Rupak K., Anderson, Bethany D., Geye, Heather M., Bentzen, Søren M., Cannon, George M.
Format: Article
Language:English
Subjects:
Brachytherapy - adverse effects
Breast Neoplasms - complications
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Breast Oncology
Carcinoma, Ductal, Breast - complications
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Carcinoma, Ductal, Breast - radiotherapy
Carcinoma, Lobular - complications
Carcinoma, Lobular - metabolism
Carcinoma, Lobular - pathology
Carcinoma, Lobular - radiotherapy
Cohort Studies
Estrogen Receptor alpha - metabolism
Female
Follow-Up Studies
Humans
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - etiology
Neoplasm Recurrence, Local - metabolism
Neoplasm Staging
Oncology
Prognosis
Radiotherapy Dosage
Risk Factors
Surgery
Surgical Oncology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Understanding risk factors for locoregional recurrence (LRR) after accelerated partial breast irradiation (APBI) can help to guide patient selection for treatment with APBI. Published findings to date have not been consistent. More data are needed as these risk factors continue to be defined. Methods A total of 277 women with early-stage invasive breast cancer underwent lumpectomy and were treated adjuvantly at our institution with APBI using high-dose rate brachytherapy. APBI was delivered using multicatheter interstitial brachytherapy (91 %) or single-entry catheter brachytherapy (9 %) to a dose of 32–34 Gy in 8–10 twice daily fractions. Failure patterns and risk factors for recurrence were analyzed. Results With a median follow-up of 61 months, the 5-year locoregional control rate was 94.4 %. Negative estrogen receptor (ER) status was strongly associated with LRR on multivariate analysis ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-013-3015-5