Synthesis and Evaluation of Some New (1,2,4) Triazolo(4,3-a)Quinoxalin-4(5H)-one Derivatives as AMPA Receptor Antagonists

This study involves the synthesis and anticonvulsant evaluation of 1‐ethyl‐3‐hydrazinylquinoxaline‐2‐(1H)‐one (8), its chemical confirmations 9 and 10 and certain (1,2,4) triazolo(4,3‐a)quinoxalin‐4(5H)‐one compounds 11, 12, 13, 13a, 13b, 13c, 13d, 13e, 13f, 14, 15, 16. The structure of the synthesi...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2013-09, Vol.50 (5), p.1202-1208
Main Authors: Abul-Khair, Hamada, Elmeligie, Salwa, Bayoumi, Ashraf, Ghiaty, Adel, El-Morsy, Ahmed, Hassan, Memy H.
Format: Article
Language:English
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Summary:This study involves the synthesis and anticonvulsant evaluation of 1‐ethyl‐3‐hydrazinylquinoxaline‐2‐(1H)‐one (8), its chemical confirmations 9 and 10 and certain (1,2,4) triazolo(4,3‐a)quinoxalin‐4(5H)‐one compounds 11, 12, 13, 13a, 13b, 13c, 13d, 13e, 13f, 14, 15, 16. The structure of the synthesized compounds was confirmed chemically by elemental analyses and spectral data (IR, 1H NMR, 13C NMR, and Mass). Docking studies were preformed to all of the synthesized compounds to predict, in a qualitative way, the anticonvulsant activity of the proposed compounds. There is a promising correlation between the results of molecular modeling and the anticonvulsant activity of the synthesized compounds. The highest fitting value was noticed for compounds 9 and 10, which showed the highest anticonvulsant activity.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.714