Effect of Diet on Some Rat Liver Plasma Membrane and Intestinal Enzymes in Subacute Galactosamine Hepatitis

The biochemical changes in male Wistar rats with galactosamine-induced (total dose —2.78mmol/kg body mass, divided equally into three i.p. injections) hepatitis maintained on high-protein (46% casein) or glucose (63%) diets were studied. The diets containing glucose instead of starch reduced the eff...

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Bibliographic Details
Published in:Journal of Clinical Biochemistry and Nutrition 1987, Vol.2(3), pp.261-268
Main Authors: NIKOLAEV, V., NAYDENOVA, E., KERIMOVA, M., IVANOV, E., DONTCHEV, N., BOROV, B.
Format: Article
Language:English
Subjects:
diet
disaccharidases
galactosamine hepatitis
liver plasma membrane
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Summary:The biochemical changes in male Wistar rats with galactosamine-induced (total dose —2.78mmol/kg body mass, divided equally into three i.p. injections) hepatitis maintained on high-protein (46% casein) or glucose (63%) diets were studied. The diets containing glucose instead of starch reduced the effects of galactosamine on serum aspartate and alanine aminotransferase activities and on 5′-nucleotidase, K+, Na+- and Mg++-adenosine triphosphatase activities in liver plasma membrane preparations. A diminished content of reduced glutathione in liver homogenates of the galactosamine treated animals fed glucose-containing diets was established. Liver microsomal cytochrome P-450 concentration showed no significant changes. The activities of some intestinal disaccharidases were increased, however, by galactosamine treatment. The data suggest that intestinal epithelium may also be a target in this hepatic lesion.
ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.2.261