Pathogenesis of 4-Aminopyrazolopyrimidine (4-APP)-Induced Fatty Liver

4-Aminopyrazolopyrimidine (4-APP)-induced fatty livers were analyzed biochemically and immunohistochemically. Biochemically, lipid peroxide levels measured by thiobarbituric acid method in the rat liver homogenates were markedly increased following 4-APP administration. However, glutathione peroxida...

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Published in:Journal of clinical biochemistry and nutrition 1987, Vol.3 (3), p.195-199
Main Authors: MURAKOSHI, Masanori, TAKEKOSHI, Susumu, MISAWA, Mitsuko, WATANABE, Keiichi
Format: Article
Language:English
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Summary:4-Aminopyrazolopyrimidine (4-APP)-induced fatty livers were analyzed biochemically and immunohistochemically. Biochemically, lipid peroxide levels measured by thiobarbituric acid method in the rat liver homogenates were markedly increased following 4-APP administration. However, glutathione peroxidase (GSH-PO) activity in the same homogenates was decreased. In addition, immunohistochemical localization of GSH-PO in 4-APP-treated rat liver was also decreased. Based on our data, we strongly suggested that pathogenesis of 4-APP induced-fatty liver may be due to uncontrolled free radical formation, peroxidation of lipids, and an associated lipid accumulation in the liver.
ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.3.195