Glycosylation and Placental Transport of Immunoglobulin G

In order to investigate the relationship between the changes in glycosylation and the placental materno-fetal transport of Immunoglobulin G (IgG), glycosylation profiles of IgG from healthy pregnant women and their umbilical cords at delivery were compared by use of a recently established high-perfo...

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Bibliographic Details
Published in:Journal of Clinical Biochemistry and Nutrition 1996, Vol.21(1), pp.57-63
Main Authors: KIBE, Tetsuya, FUJIMOTO, Shinji, ISHIDA, Chizu, TOGARI, Hajime, WADA, Yoshiro, OKADA, Setsuo, NAKAGAWA, Hiroaki, TSUKAMOTO, Yoshinori, TAKAHASHI, Noriko
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
IgG galactosylation
Mother. Fetoplacental unit. Mammary gland. Milk
N-linked oligosaccharides
newborn
placental transport
pregnancy
Pregnancy. Parturition. Lactation
Vertebrates: reproduction
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Summary:In order to investigate the relationship between the changes in glycosylation and the placental materno-fetal transport of Immunoglobulin G (IgG), glycosylation profiles of IgG from healthy pregnant women and their umbilical cords at delivery were compared by use of a recently established high-performance liquid chromatography (HPLC) method. From the results of neutral oligosaccharide analysis, the digalactosyl IgG glycoform (G2) was markedly increased in pregnant women as compared with that in age-matched controls. Furthermore, the quantity of the digalactosyl glycoform in the umbilical cord was found to be higher than that in the mother. These findings demonstrate the existence of a placental selective transport with a preference for a digalactosyl oligosaccharide-linked IgG molecule. Concerning IgG sialo-oligosaccharides, however, no selective transport was observed between mother and umbilical cord. The mechanism and clinical importance of greater galactosylation in IgG still remain unclear, but we suggest that the relationship between changes in IgG galactosylation and the placental selective transport deserves further attention.
ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.21.57