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Ethanol Effects on Intestinal Functions in Giardia lamblia-Infected Rats
The effect of Giardia lamblia infection on D-glucose uptake and brush-border enzymes was studied in chronically ethanol-fed rats. Giardia lamblia trophozoites counts were significantly lower in the intestine of ethanol-fed rats than in the controls. Also, the Na+-dependent uptake of D-glucose and br...
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Published in: | Journal of Clinical Biochemistry and Nutrition 1999, Vol.26(1), pp.17-25 |
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creator | MITTAL, Nidhi NAGPAUL, Joginder Pal MAHMOOD, Safrun MAHMOOD, Akhtar |
description | The effect of Giardia lamblia infection on D-glucose uptake and brush-border enzymes was studied in chronically ethanol-fed rats. Giardia lamblia trophozoites counts were significantly lower in the intestine of ethanol-fed rats than in the controls. Also, the Na+-dependent uptake of D-glucose and brush-border enzymes was significantly reduced (p |
doi_str_mv | 10.3164/jcbn.26.17 |
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Giardia lamblia trophozoites counts were significantly lower in the intestine of ethanol-fed rats than in the controls. Also, the Na+-dependent uptake of D-glucose and brush-border enzymes was significantly reduced (p<0.0001, p<0.01, respectively) in the G. lamblia-infected rat intestine. There was no change in Na+-independent glucose uptake under these conditions. Levels of mRNA encoding Na+-dependent D-glucose transporter (SGLT1) and brush-border sucrase and lactase were reduced in G. lamblia-infected animals compared with those of the controls. However, the mRNA levels encoding these proteins in ethanol-fed and control animals were similar in rat intestine. These findings suggest that down-regulation of SGLT1 and disaccharidases could be responsible for the observed D-glucose malabsorption and decrease in the activity of disaccharidases in G. lamblia infection.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.26.17</identifier><language>eng</language><publisher>Tokyo: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>Amibiasis ; Biological and medical sciences ; disaccharidases ; ethanol feeding ; Giardia lamblia ; Human protozoal diseases ; Infectious diseases ; malabsorption ; Medical sciences ; Miscellaneous ; Parasitic diseases ; Protozoal diseases ; sugar transport (D-glucose)</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 1999, Vol.26(1), pp.17-25</ispartof><rights>The Editorial Secretariat of JCBN</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-7d06d33974c7efd5e934e440c8bdf8cd5f4b6c37f7cdb276f130ace499e4d7ec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1902439$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>MITTAL, Nidhi</creatorcontrib><creatorcontrib>NAGPAUL, Joginder Pal</creatorcontrib><creatorcontrib>MAHMOOD, Safrun</creatorcontrib><creatorcontrib>MAHMOOD, Akhtar</creatorcontrib><title>Ethanol Effects on Intestinal Functions in Giardia lamblia-Infected Rats</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>The effect of Giardia lamblia infection on D-glucose uptake and brush-border enzymes was studied in chronically ethanol-fed rats. Giardia lamblia trophozoites counts were significantly lower in the intestine of ethanol-fed rats than in the controls. Also, the Na+-dependent uptake of D-glucose and brush-border enzymes was significantly reduced (p<0.0001, p<0.01, respectively) in the G. lamblia-infected rat intestine. There was no change in Na+-independent glucose uptake under these conditions. Levels of mRNA encoding Na+-dependent D-glucose transporter (SGLT1) and brush-border sucrase and lactase were reduced in G. lamblia-infected animals compared with those of the controls. However, the mRNA levels encoding these proteins in ethanol-fed and control animals were similar in rat intestine. These findings suggest that down-regulation of SGLT1 and disaccharidases could be responsible for the observed D-glucose malabsorption and decrease in the activity of disaccharidases in G. lamblia infection.</description><subject>Amibiasis</subject><subject>Biological and medical sciences</subject><subject>disaccharidases</subject><subject>ethanol feeding</subject><subject>Giardia lamblia</subject><subject>Human protozoal diseases</subject><subject>Infectious diseases</subject><subject>malabsorption</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Parasitic diseases</subject><subject>Protozoal diseases</subject><subject>sugar transport (D-glucose)</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LAzEYhIMoWKsXf0FAT8LWZJNNNkcp_YKCIHoO2XzYlG22JunBf--2W-rlfQ_zzDAMAI8YTQhm9HWrmzAp2QTzKzDCdY2KCtXsGoyQwGWBEBK34C6lLUKUVYyOwHKWNyp0LZw5Z3VOsAtwFbJN2QfVwvkh6Oy7kKAPcOFVNF7BVu2a1qtiFY4Wa-CHyuke3DjVJvtw_mPwNZ99TpfF-n2xmr6tC11RkQtuEDOECE41t85UVhBqKUW6boyrtakcbZgm3HFtmpIzhwlS2lIhLDXcajIGT0PuPnY_h76n3HaH2HdNElOKBUYUs556GSgdu5SidXIf_U7FX4mRPC4lj0vJkknMe_j5HKmSVq2LKmif_h0ClZSIHpsO2DZl9W0vuorZ69aeErGo2Sl1OJhfVL1RUdpA_gD5hIDQ</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>MITTAL, Nidhi</creator><creator>NAGPAUL, Joginder Pal</creator><creator>MAHMOOD, Safrun</creator><creator>MAHMOOD, Akhtar</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Institute of Applied Biochemistry</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>1999</creationdate><title>Ethanol Effects on Intestinal Functions in Giardia lamblia-Infected Rats</title><author>MITTAL, Nidhi ; NAGPAUL, Joginder Pal ; MAHMOOD, Safrun ; MAHMOOD, Akhtar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-7d06d33974c7efd5e934e440c8bdf8cd5f4b6c37f7cdb276f130ace499e4d7ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amibiasis</topic><topic>Biological and medical sciences</topic><topic>disaccharidases</topic><topic>ethanol feeding</topic><topic>Giardia lamblia</topic><topic>Human protozoal diseases</topic><topic>Infectious diseases</topic><topic>malabsorption</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Parasitic diseases</topic><topic>Protozoal diseases</topic><topic>sugar transport (D-glucose)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MITTAL, Nidhi</creatorcontrib><creatorcontrib>NAGPAUL, Joginder Pal</creatorcontrib><creatorcontrib>MAHMOOD, Safrun</creatorcontrib><creatorcontrib>MAHMOOD, Akhtar</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MITTAL, Nidhi</au><au>NAGPAUL, Joginder Pal</au><au>MAHMOOD, Safrun</au><au>MAHMOOD, Akhtar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanol Effects on Intestinal Functions in Giardia lamblia-Infected Rats</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>1999</date><risdate>1999</risdate><volume>26</volume><issue>1</issue><spage>17</spage><epage>25</epage><pages>17-25</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>The effect of Giardia lamblia infection on D-glucose uptake and brush-border enzymes was studied in chronically ethanol-fed rats. Giardia lamblia trophozoites counts were significantly lower in the intestine of ethanol-fed rats than in the controls. Also, the Na+-dependent uptake of D-glucose and brush-border enzymes was significantly reduced (p<0.0001, p<0.01, respectively) in the G. lamblia-infected rat intestine. There was no change in Na+-independent glucose uptake under these conditions. Levels of mRNA encoding Na+-dependent D-glucose transporter (SGLT1) and brush-border sucrase and lactase were reduced in G. lamblia-infected animals compared with those of the controls. However, the mRNA levels encoding these proteins in ethanol-fed and control animals were similar in rat intestine. These findings suggest that down-regulation of SGLT1 and disaccharidases could be responsible for the observed D-glucose malabsorption and decrease in the activity of disaccharidases in G. lamblia infection.</abstract><cop>Tokyo</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><doi>10.3164/jcbn.26.17</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Amibiasis Biological and medical sciences disaccharidases ethanol feeding Giardia lamblia Human protozoal diseases Infectious diseases malabsorption Medical sciences Miscellaneous Parasitic diseases Protozoal diseases sugar transport (D-glucose) |
title | Ethanol Effects on Intestinal Functions in Giardia lamblia-Infected Rats |
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