Coenzyme Q10 and Its Role in Heart Disease

Coenzyme Q10 (CoQ10) deficiency has been observed in apparently healthy subjects as well as in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse and after coronary revascularization. CoQ10 bolsters the synthesis of A...

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Bibliographic Details
Published in:Journal of Clinical Biochemistry and Nutrition 1999, Vol.26(2), pp.109-118
Main Authors: SINGH, Ram B., NIAZ, Mohammad A., RASTOGI, Shanti S., VERMA, Satya P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
cardiomyopathy
coronary artery disease
heart failure
hypertension
Medical sciences
Metabolic diseases
myocardial infarction
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
ubiquinone
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Summary:Coenzyme Q10 (CoQ10) deficiency has been observed in apparently healthy subjects as well as in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse and after coronary revascularization. CoQ10 bolsters the synthesis of ATP and inhibits free radical damage, hence is useful in preventing cellular damage during ischaemia-reperfusion injury. The clinical benefits are mainly due to its ability to improve energy production, antioxidant activity, and membrane stabilizing properties. Several small scale studies indicate that coenzyme Q could be useful in patients with congestive heart failure, angina pectoris, cardiomyopathy, coronary artery disease, acute myocardial infarction and in the preservation of myocardium. CoQ10 may also decrease lipoprotein (a) and plasma insulin. CoQ10 is normally present in the low-density lipoprotein cholesterol fraction and inhibits its oxidation indicating that it can inhibit atherosclerosis. It can also regenerate vitamin E. CoQ10 is known for producing minor gastrointestinal discomfort and elevation in SGOT and LDH when used.
ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.26.109