Effect of Oral Administration of L-Arginine and L-Lysine on Lipid Metabolism against Isoproterenol-induced Myocardial Infarction in Rats

The protective effects of L-arginine in combination with L-lysine on lipid metabolism were examined against isoproterenol-induced myocardial infarction in rats. The levels of cholesterol, triacylglycerols and free fatty acids were estimated both in serum and the myocardial tissue.The levels of LDL-...

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Bibliographic Details
Published in:Journal of Clinical Biochemistry and Nutrition 2003, Vol.33(1), pp.7-11
Main Authors: Ebenezar, Kesavarao Kumar, Sathish, Venkatachalem, Devaki, Thiruvengadam
Format: Article
Language:English
Subjects:
cardioprotection
isoproterenol
L-arginine
L-lysine
lipid metabolism
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Summary:The protective effects of L-arginine in combination with L-lysine on lipid metabolism were examined against isoproterenol-induced myocardial infarction in rats. The levels of cholesterol, triacylglycerols and free fatty acids were estimated both in serum and the myocardial tissue.The levels of LDL- and HDL-cholesterol in serum and phospholipids in the myocardial tissues were also estimated in the normal and experimental rats. The rats administered isoproterenol (150mg kg-1 daily, intraperitoneally) showed significant changes in the lipid components. Prior oral treatment with L-arginine (250mg kg-1 daily) along with L-lysine (5mg kg-1 daily) in alleviating isoproterenol-induced biochemical disturbances with respect to lipid metabolism has been the hallmark of the study.
ISSN:0912-0009
1880-5086
DOI:10.3164/jcbn.33.7