DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru([eta]6-arene)Cl2] Drug Candidates

Slipped under the radar? (1) HNMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for re...

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Bibliographic Details
Published in:Chemistry : a European journal 2013-10, Vol.19 (44), p.14768
Main Authors: Patra, Malay, Joshi, Tanmaya, Pierroz, Vanessa, Ingram, Katrin, Kaiser, Marcel, Ferrari, Stefano, Spingler, Bernhard, Keiser, Jennifer, Gasser, Gilles
Format: Article
Language:English
Subjects:
Chemistry
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Summary:Slipped under the radar? (1) HNMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201303341