DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru([eta]6-arene)Cl2] Drug Candidates

Slipped under the radar? (1) HNMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for re...

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Published in:Chemistry : a European journal 2013-10, Vol.19 (44), p.14768
Main Authors: Patra, Malay, Joshi, Tanmaya, Pierroz, Vanessa, Ingram, Katrin, Kaiser, Marcel, Ferrari, Stefano, Spingler, Bernhard, Keiser, Jennifer, Gasser, Gilles
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container_issue 44
container_start_page 14768
container_title Chemistry : a European journal
container_volume 19
creator Patra, Malay
Joshi, Tanmaya
Pierroz, Vanessa
Ingram, Katrin
Kaiser, Marcel
Ferrari, Stefano
Spingler, Bernhard
Keiser, Jennifer
Gasser, Gilles
description Slipped under the radar? (1) HNMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.
doi_str_mv 10.1002/chem.201303341
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title DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity of N-Heterocyclic-[Ru([eta]6-arene)Cl2] Drug Candidates
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