Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives

A number of isoindole ( 3x , 3y , 6xa – 6ye ), pyrrolopyrazine ( 3z , 6za – 6ze ), benzimidazoisoindole ( 4x , 4y , 7xa – 7ye ), and benzimidazopyrrolopyrazine ( 4z , 7za – 7ze ) derivatives has been synthesized in excellent yields. All these compounds were fully characterized and evaluated against...

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Bibliographic Details
Published in:Molecular diversity 2013-11, Vol.17 (4), p.753-766
Main Authors: Kumar, Sandeep, Kumar, Nikhil, Roy, Partha, Sondhi, Sham M.
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biochemistry
Biomedical and Life Sciences
Biomedical research
Biosynthesis
Cancer therapies
Cell Line, Tumor
Full-Length Paper
Humans
Inhibitory Concentration 50
Isoindoles - chemical synthesis
Isoindoles - pharmacology
Life Sciences
Molecular Structure
Natural products
Organic Chemistry
Pharmacy
Polymer Sciences
Structure-Activity Relationship
Studies
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Summary:A number of isoindole ( 3x , 3y , 6xa – 6ye ), pyrrolopyrazine ( 3z , 6za – 6ze ), benzimidazoisoindole ( 4x , 4y , 7xa – 7ye ), and benzimidazopyrrolopyrazine ( 4z , 7za – 7ze ) derivatives has been synthesized in excellent yields. All these compounds were fully characterized and evaluated against five human cancer cell lines for their anti-inflammatory and antiproliferative activity. Compounds 6yc and 7zd exhibited good anti-inflammatory activity whereas compounds 6zc , 7zd (lung NCl H-522), 6ye , 7xd , 7yd , 7zc , 7zd (colon HCT-15), 6xc , 7zc (ovary PA-1), 6xc , 6yb , 6zc (liver HepG-2) exhibited good antiproliferative activity.
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-013-9472-8