Measurement of Nicotine in Indoor Air Collected by Alkaline-coated Solid Phase Cartridge Followed by GC-MS Analysis

Nicotine has been used as a selective marker to evaluate environmental tobacco smoke (ETS). In this study, a simple and precise nicotine measurement method using a solid phase cartridge (Sep-Pak® Plus PS-2) followed by GC-MS analysis was evaluated. Prior to use, the solid phase cartridge was coated...

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Bibliographic Details
Published in:Journal of Health Science 2007, Vol.53(1), pp.53-59
Main Authors: Saito, Ikue, Seto, Hiroshi
Format: Article
Language:English
Subjects:
environmental tobacco smoke
indoor air
nicotine
Sep-Pak® Plus PS-2
smoking room
solid phase cartridge
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Summary:Nicotine has been used as a selective marker to evaluate environmental tobacco smoke (ETS). In this study, a simple and precise nicotine measurement method using a solid phase cartridge (Sep-Pak® Plus PS-2) followed by GC-MS analysis was evaluated. Prior to use, the solid phase cartridge was coated with potassium hydroxide (KOH), and indoor air was then passed through it. After the air sampling, nicotine was eluted from the cartridge with 10μg/ml triethylamine/dichloromethane, and the eluent was analyzed by GC-MS. The nicotine recovery from the spiked cartridge was more than 80% for an air sampling time of 12hr, and the method detection limit (MDL) for the air sampling with an air volume of 721 was 0.35μg/m3. When the cartridge was used for indoor air measurement, the nicotine concentrations in the smoking room ranged from 12.9μg/m3 to 86.6μg/m3, which were proportional to the number of smoked cigarettes.
ISSN:1344-9702
1347-5207
DOI:10.1248/jhs.53.53