Anti-diabetic Activity of Methanol Leaf Extract of Costus pictus D. DON in Alloxan-induced Diabetic Rats

The methanol extract of Costus pictus (C. pictus) D. DON (Family: Zingiberaceae) leaf was investigated for its anti-diabetic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of single doses of alloxan monohydrate (120 mg/kg, i.p.). The methanol extract of C. pictus...

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Published in:Journal of Health Science 2007, Vol.53(6), pp.655-663
Main Authors: Jothivel, Nandhakumar, Ponnusamy, Sethumathi Pudhupalayam, Appachi, Malini, Singaravel, Sengottuvelu, Rasilingam, Duraisamy, Deivasigamani, Karthikeyan, Thangavel, Sivakumar
Format: Article
Language:English
Subjects:
alloxan
anti-diabetic
Costus pictus
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Summary:The methanol extract of Costus pictus (C. pictus) D. DON (Family: Zingiberaceae) leaf was investigated for its anti-diabetic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of single doses of alloxan monohydrate (120 mg/kg, i.p.). The methanol extract of C. pictus (MECP) at a dose of 120 mg/kg, p.o. was administered as single dose per day to diabetes-induced rats for a period of 21 days. The effect of MECP leaf extract on blood glucose, plasma insulin, serum lipid profile [cholesterol, triglycerides, phospholipids, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL)], serum enzymes [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), alkaline phosphatase (ALP)], total protein, and liver glycogen were measured in the diabetic rats. Histopathological studies of liver, pancreas and kidney were also carried out. MECP elicited significant (p
ISSN:1344-9702
1347-5207
DOI:10.1248/jhs.53.655