Hypothermia after Reperfusion Suppresses Aggravation of Acute Brain Edema following Transient Forebrain Ischemia in Mice

In our previous paper, we reported that spontaneous hypothermia (HT) during ischemia protects against delayed neuronal death in the hippocampus but not against acute brain edema following transient forebrain ischemia, which is induced by occlusion of the bilateral common carotid arteries (BCCA) in C...

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Bibliographic Details
Published in:Journal of Health Science 2011, Vol.57(1), pp.82-85
Main Authors: Doshi, Masaru, Higuchi, Etsuka, Hirashima, Yutaka
Format: Article
Language:English
Subjects:
brain edema
cerebral ischemia
hypothermia
mouse
reperfusion
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Summary:In our previous paper, we reported that spontaneous hypothermia (HT) during ischemia protects against delayed neuronal death in the hippocampus but not against acute brain edema following transient forebrain ischemia, which is induced by occlusion of the bilateral common carotid arteries (BCCA) in C57BL/6J mice. We here demonstrate that artificial HT after reperfusion (rHT) suppresses the aggravation of acute brain edema in the BCCA occlusion C57BL/6J mouse model. Our results suggest that mechanisms regulated by rHT are involved in the attenuation of acute brain edema after reperfusion in this model of cerebral ischemia.
ISSN:1344-9702
1347-5207
DOI:10.1248/jhs.57.82