Palladium-Catalyzed Direct Acylation of Ketoximes and Aldoximes from the Alcohol Oxidation Level through C-H Bond Activation

A highly efficient palladium‐catalyzed oxidative ortho‐acylation of O‐methyl ketoximes and O‐methyl aldoximes with benzylic and aliphatic alcohols from the alcohol oxidation level is described. This protocol potentially provides new opportunities to use readily available alcohols as starting materia...

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Bibliographic Details
Published in:European journal of organic chemistry 2013-10, Vol.2013 (29), p.6656-6665
Main Authors: Sharma, Satyasheel, Kim, Minyoung, Park, Jihye, Kim, Mirim, Kwak, Jong Hwan, Jung, Young Hoon, Oh, Joa Sub, Lee, Youngil, Kim, In Su
Format: Article
Language:English
Subjects:
Acylation
Alcohol
Alcohols
C-H Activation
Oxidation
Oximes
Palladium
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Summary:A highly efficient palladium‐catalyzed oxidative ortho‐acylation of O‐methyl ketoximes and O‐methyl aldoximes with benzylic and aliphatic alcohols from the alcohol oxidation level is described. This protocol potentially provides new opportunities to use readily available alcohols as starting materials for catalytic reactions, and represents a catalytic alternative to transcend the barriers imposed by classical Friedel–Crafts acylation. A highly efficient palladium‐catalyzed oxidative ortho‐acylation of O‐methyl ketoximes and O‐methyl aldoximes with benzylic and aliphatic alcohols from the alcohol oxidation level is described.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201300649