Refractoriness to platelet transfusion in acute myeloid leukemia correlated with the optical density of anti-platelet factor 4/heparin antibodies

• Published in: International journal of hematology 2013-10, Vol.98 (4), p.472-477
• Main Authors: Aimoto, Mizuki, Yamane, Takahisa, Shiomoto, Kazumasa, Sakamoto, Chikahiko, Nakashima, Yasuhiro, Koh, Hideo, Nakane, Takahiko, Takeoka, Yasunobu, Hirose, Asao, Nakamae, Mika, Hagihara, Kiyoyuki, Terada, Yoshiki, Nakao, Yoshitaka, Nakamae, Hirohisa, Hino, Masayuki, Miyata, Shigeki
• Format: Article
• Language: English
• Subjects: Aged; Antibodies - blood; Antibodies - immunology; Biological and medical sciences; Case Report; Female; Hematologic and hematopoietic diseases; Hematology; Heparin - adverse effects; Heparin - immunology; Humans; Leukemia, Myeloid, Acute - blood; Leukemia, Myeloid, Acute - immunology; Leukemia, Myeloid, Acute - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Medicine; Medicine & Public Health; Oncology; Platelet Count; Platelet diseases and coagulopathies; Platelet Factor 4 - immunology; Platelet Transfusion - adverse effects; Thrombocytopenia - chemically induced; Thrombocytopenia - therapy
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-013-1427-4

A small number of reports have described cases of heparin-induced thrombocytopenia complicating hematological disorders with impaired platelet production. We describe the case of a 66-year-old woman with acute myeloid leukemia who exhibited unexplained refractoriness to platelet transfusion, while receiving heparin flushes, and was found to have anti-platelet factor 4 (PF4)/heparin antibodies with high optical density (OD) values (>2 units) detected by an enzyme-linked immunosorbent assay. After cessation of heparin flushes, her refractoriness to platelet transfusion resolved. We retrospectively confirmed that the OD values for anti-PF4/heparin antibodies declined gradually; refractoriness to platelet transfusion resolved when the OD values fell below 1.0 units. Given the absence of any other evident explanation for this phenomenon, and the correlation between the OD values for anti-PF4/heparin antibodies and the efficacy of platelet transfusions, we conclude that the patient’s refractoriness to platelet transfusion was most likely caused by anti-PF4/heparin antibodies that had platelet-activating properties.