Studies on Mutagenicity of Sumithion®, Cremart® and Denmert

• Published in: Journal of Pesticide Science 1976/11/20, Vol.1(4), pp.253-259
• Main Authors: SUZUKI, Hiroshi, MIYAMOTO, Junshi
• Format: Article
• Language: English
• ISSN: 1348-589X; 1349-0923
• DOI: 10.1584/jpestics.1.253

The genetic toxicity of insecticidal Sumithion (O, O-Dimethyl (3-Methyl 4-Nitrophenyl) Phosphorothioate), herbicidal Cremart (O-Ethyl O-(3-Methyl 6-Nitrophenyl) N-sec-Butyl Phosphorothioamidate) and fungicidal Denmert (S-n-Butyl S′-p-tent-Butylbenzyl N-3-Pyridyldithiocarbonimidate) was examined by bacterial systems with two different methods, that is 1) by measuring the reverse mutation frequency of nutrient-deficient mutants, and 2) by estimating DNA damaging capacity through detection of difference in growth inhibition of chemicals between DNA repair-deficient strains and wild types. Two further examinations were carried out to estimate the possible mutagenic effect of mammalian metabolites by combaining with in vitro drug metabolizing systems, and by ‘host-mediated assay’ as an in vivo system. In any examination Sumithion, Cremart or Denmert at the highest possible dosage was found to be neither mutagenic nor radiomimetic, whereas nitrosoguanidine, 2-aminoanthracene or dimethylnitrosamine was strongly mutagenic in appropriate test systems.