Mesenteric lymph duct ligation decreases red blood cell alterations caused by acute pancreatitis

Both experimental and clinical studies have shown that acute pancreatitis (AP) causes a significant decrease in red blood cell (RBC) deformability. The mechanisms by which AP induces RBC injury are unknown. The purpose of this study was to test the hypothesis that factors carried in the mesenteric l...

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Bibliographic Details
Published in:The American journal of surgery 2005-11, Vol.190 (5), p.800-804
Main Authors: Berezina, Tamara L., Zaets, Sergey B., Mole, Damian J., Spolarics, Zoltan, Deitch, Edwin A., Machiedo, George W.
Format: Article
Language:English
Subjects:
Acute pancreatitis
Animals
Biological and medical sciences
Blood
Cell Size
Disease Models, Animal
Erythrocyte Deformability
Erythrocytes - pathology
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Laser Scanning Cytometry
Laser-assisted ektacytometry
Ligation
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Lymphatic Vessels - surgery
Male
Medical sciences
Mesenteric lymph
Mesentery
Multiple Organ Failure - blood
Multiple Organ Failure - etiology
Multiple Organ Failure - prevention & control
Other diseases. Semiology
Pancreatitis, Acute Necrotizing - blood
Pancreatitis, Acute Necrotizing - complications
Permeability
Rats
Rats, Sprague-Dawley
Red blood cell deformability
Rodents
Studies
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Summary:Both experimental and clinical studies have shown that acute pancreatitis (AP) causes a significant decrease in red blood cell (RBC) deformability. The mechanisms by which AP induces RBC injury are unknown. The purpose of this study was to test the hypothesis that factors carried in the mesenteric lymph after an attack of AP significantly contribute to the RBC injury observed in AP. RBC deformability was determined by means of laser-assisted ektacytometry in mesenteric lymph duct–ligated and non-ligated rats subjected to AP and in sham-operated animals. AP was associated with significant alterations of RBC deformability indices, namely the elongation index and half maximal RBC elongation. Pancreatitis-induced RBC deformability changes were partially prevented by mesenteric lymph duct ligation. Mesenteric lymph in AP contains factors that cause RBC damage, which is manifested by decreased deformability. Interruption of the lymph flow from the injured gut into the bloodstream decreases these RBC alterations.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2005.07.023