Lipopolysaccharide sensing on the inside

Host-cell detection of lipopolysaccharide in the outer membrane of Gram-negative bacteria was thought to be restricted to the cell-surface receptor TLR4. It emerges that lipopolysaccharide can also be sensed in the cytoplasm.

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Bibliographic Details
Published in:Nature (London) 2013-09, Vol.501 (7466), p.173-175
Main Authors: Rathinam, Vijay A. K., Fitzgerald, Katherine A.
Format: Article
Language:English
Subjects:
631/250
631/80
Bacteria
Bacterial infections
Cytoplasm
E coli
Enzymes
Gram-negative bacteria
Humanities and Social Sciences
Immunology
Infections
Lipids
Lipopolysaccharides
Macrophages
Microbiology
Mortality
multidisciplinary
news-and-views
Physiological aspects
Rodents
Science
Sepsis
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Description
Summary:Host-cell detection of lipopolysaccharide in the outer membrane of Gram-negative bacteria was thought to be restricted to the cell-surface receptor TLR4. It emerges that lipopolysaccharide can also be sensed in the cytoplasm.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature12556