S-Nitroso-[beta]-Cyclodextrins as New Bimodal Carriers: Preparation, Detailed Characterization, Nitric-Oxide Release, and Molecular Encapsulation

I can't get NO satisfaction: 6-Mono- and 6-multi-S-nitroso-[beta]-cyclodextrins (SNO-[beta]CDs) were characterized in terms of their SNO content, conformational preference, thermal and photochemical release of NO, and their ability to encapsulate guest molecules, as well as cell permeation and...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2013-11, Vol.8 (11), p.2768
Main Authors: Piras, Linda, Theodossiou, Theodossis A, Manouilidou, Malamatenia D, Lazarou, Yannis G, Sortino, Salvatore, Yannakopoulou, Konstantina
Format: Article
Language:English
Subjects:
Chemistry
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Summary:I can't get NO satisfaction: 6-Mono- and 6-multi-S-nitroso-[beta]-cyclodextrins (SNO-[beta]CDs) were characterized in terms of their SNO content, conformational preference, thermal and photochemical release of NO, and their ability to encapsulate guest molecules, as well as cell permeation and toxicity. SNO-[beta]CDs are promising bimodal molecules of satisfactory stability that combine photochemically or thermally induced NO release with drug-carrier ability.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201300543