Protein Structural Characterization by Scanning Tunneling Microscopy with Electrochemistry

The structure characterization of proteins or enzymes by STM on electrochemically prepared HOPG surface studied in this laboratory is reviewed. The serial structures of Hb were observed. The differences between the denaturation and inactivation of HRP were investigated by in situ and ex situ STM. Th...

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Bibliographic Details
Published in:Analytical Sciences 2000, Vol.16(2), pp.205-209
Main Authors: WANG, Erkang, WANG, Hongda, LI, Zhuang
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods
Proteins
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Summary:The structure characterization of proteins or enzymes by STM on electrochemically prepared HOPG surface studied in this laboratory is reviewed. The serial structures of Hb were observed. The differences between the denaturation and inactivation of HRP were investigated by in situ and ex situ STM. The structural variation of Hb in an organic solvent was imaged while protein denaturation was easily observed in a polar solvent.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.16.205