Impact of Environmental Factors on Efficacy of Glucocorticoids in Chinese Population with Systemic Lupus Erythematosus

Although glucocorticoids (GCs) are effective in inducing remission in systemic lupus erythematosus (SLE) patients, there is a significant variation in response to therapeutic GCs, and some patients do not achieve full remission. The aim of this study was to explore the impact of environmental factor...

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Published in:Inflammation 2013-12, Vol.36 (6), p.1424-1430
Main Authors: Zou, Yan-Feng, Xu, Jian-Hua, Tao, Jin-Hui, Xu, Sheng-Qian, Liu, Shuang, Chen, Shan-Yu, Cai, Jing, Lian, Li, Chen, Pei-Ling, Wang, De-Guang, Liu, Sheng-Xiu, Liang, Chun-Mei, Ye, Qian-Ling, Tian, Guo, Wu, Min, Pan, Hai-Feng, Pan, Fa-Ming, Su, Hong, Ye, Dong-Qing
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
China
Cohort Studies
Environmental Exposure - adverse effects
Female
Glucocorticoids - therapeutic use
Humans
Hypersensitivity
Immunology
Internal Medicine
Life Change Events
Lupus Erythematosus, Systemic - drug therapy
Male
Pathology
Personality
Pharmacology/Toxicology
Prednisone - therapeutic use
Prospective Studies
Rheumatology
Sodium Chloride
Surveys and Questionnaires
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Summary:Although glucocorticoids (GCs) are effective in inducing remission in systemic lupus erythematosus (SLE) patients, there is a significant variation in response to therapeutic GCs, and some patients do not achieve full remission. The aim of this study was to explore the impact of environmental factors on the efficacy of GCs in a Chinese population with SLE. This was a prospective cohort study, and a total of 260 SLE patients treated with GCs (prednisone) were followed up for 12 weeks. The efficacy of GCs was measured with the scores on SLE disease activity index. Environmental factors were collected using a questionnaire. Single-variable analysis and multivariate logistic regression analysis were used to discriminate the impact of environmental factors on the efficacy of GCs. Two hundred forty-seven patients (95.00 %) completed the 12-week follow-up. Among these patients, 131 (53.04 %) were classified into sensitive group and 116 (46.96 %) were classified into insensitive group. Results from logistic analysis showed that the following environmental factors were significantly associated with decreased efficacy of GCs: high salt intake (OR = 3.464, 95%CI = 1.481–8.102, P  = 0.004), introverted personality (OR = 3.550, 95%CI = 1.901–6.628, P  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-013-9682-3