MUTAGENIC ACTIVITIES OF CHIRAL EPOXIDES, HALIDES, AND N-NITROSOAMINES

Significant differences of mutagenic activities between the enantiomers of chiral epoxides, N-nitrosoamines, and halides were exhibited in Ames assay using Salmonella typhimurium TA100.

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1993/09/15, Vol.16(9), pp.942-944
Main Authors: YAGUCHI, Yoshihisa, SHIOZAWA, Tatsushi, MATSUSHITA, Hidetsuru, TERAO, Yoshiyasu
Format: Article
Language:English
Subjects:
Ames assay
Animals
Biological and medical sciences
Chemical mutagenesis
enantiomer
epoxide
Epoxy Compounds - chemistry
Epoxy Compounds - toxicity
halide
Halogens - chemistry
Halogens - toxicity
Male
Medical sciences
Microsomes, Liver - metabolism
Mutagenicity Tests
Mutagens - toxicity
N-nitrosoamine
Nitrosamines - chemistry
Nitrosamines - toxicity
Rats
Rats, Sprague-Dawley
Salmonella typhimurium
Salmonella typhimurium - genetics
Stereoisomerism
Toxicology
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Description
Summary:Significant differences of mutagenic activities between the enantiomers of chiral epoxides, N-nitrosoamines, and halides were exhibited in Ames assay using Salmonella typhimurium TA100.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.16.942