Influence of hydrocortisone on Schistosoma mansoni development in Biomphalaria glabrata

The effect of hydrocortisone on the development of BH strain of S. mansoni in B. glabrata snails is evaluated. Snails in a randomly chosen group were submitted to hydrocortisone during four days. In the second day of hydrocortisone exposure, the snails were exposed, each, to ten S. mansoni miracidia...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2002-03, Vol.35 (2), p.149
Main Authors: Serrano, Deborah Regina, Zanotti-Magalhaes, Eliana Maria, Magalhaes, Luiz Augusto, Carvalho, José Ferreira de
Format: Article
Language:eng ; por
Subjects:
Animals
Biomphalaria - parasitology
Hydrocortisone - pharmacology
Parasitic Sensitivity Tests
Schistosoma mansoni - drug effects
Schistosoma mansoni - growth & development
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Summary:The effect of hydrocortisone on the development of BH strain of S. mansoni in B. glabrata snails is evaluated. Snails in a randomly chosen group were submitted to hydrocortisone during four days. In the second day of hydrocortisone exposure, the snails were exposed, each, to ten S. mansoni miracidia. Another group, not treated with hydrocortisone, was exposed to miracidia and observed in the same manner. Various items of data were observed: the infection rate, survival time, prepatent period and total number of cercariae released. It was found that the snails in the group treated with hydrocortisone had a higher infection rate, shorter prepatent periods, produced more cercariae and also had longer survival times. This suggests that the hydrocortisone in snails induces a decrease in resistance to schistosome infection and facilitates the development of the trematode, while also reducing adverse infection effects, thereby leading to longer snail survival.
ISSN:0037-8682
1678-9849
DOI:10.1590/S0037-86822002000200004