EFFECT OF GINSENG RADIX ON GLUT2 PROTEIN CONTENT IN MOUSE LIVER IN NORMAL AND EPINEPHRINE-INDUCED HYPERGLYCEMIC MICE

The oral administration of the water extract of Ginseng Radix (GR) to normal and epinephrine-induced hyperglycemic mice caused a significant decrease in the blood glucose level 4 h after its administration. The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transpo...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1996/09/15, Vol.19(9), pp.1238-1240
Main Authors: OHNISHI, Yasuhiro, TAKAGI, Sayuki, MIURA, Toshihiro, USAMI, Masaru, KAKO, Mami, ISHIHARA, Eriko, YANO, Hideki, TANIGAWA, Keiichiro, SEINO, Yutaka
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - metabolism
Blotting, Western
Epinephrine
General and cellular metabolism. Vitamins
Ginseng Radix
Glucose Transporter Type 2
GLUT2
Hyperglycemia - chemically induced
Hyperglycemia - metabolism
hypoglycemic activity
Liver - drug effects
Liver - metabolism
Male
Medical sciences
Mice
Mice, Inbred Strains
Monosaccharide Transport Proteins - metabolism
Panax
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plants, Medicinal
Western blotting
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Summary:The oral administration of the water extract of Ginseng Radix (GR) to normal and epinephrine-induced hyperglycemic mice caused a significant decrease in the blood glucose level 4 h after its administration. The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) protein content from mouse liver significantly increased in the orally GR-treated normal and epinephrine-induced hyperglycemic mice compared to that in the controls. These results suggest that the hypoglycemic activity of GR is presumably due, at least in part, to the increment of GLUT2 protein content.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.19.1238