Antiemetic Effects of Morphine on Motion- and Drug-Induced Emesis in Suncus murinus

Emetic and antiemetic effects of morphine were investigated in Suncus murinus. Subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 μg) of morphine failed to cause emesis. However, pretreatment with morphine (s.c.) prevented the emesis induced by nicotine (10 mg/kg, i.p.), cop...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1997/07/15, Vol.20(7), pp.739-742
Main Authors: KAKIMOTO, Shuichiro, SAITO, Hiroshi, MATSUKI, Norio
Format: Article
Language:English
Subjects:
Animals
antiemetic
Antiemetics - therapeutic use
Biological and medical sciences
Cisplatin - adverse effects
Copper Sulfate - adverse effects
Digestive system
emesis
Female
Injections, Intraventricular
Injections, Subcutaneous
Male
Medical sciences
morphine
Morphine - therapeutic use
motion sickness
Motion Sickness - prevention & control
Nicotine - adverse effects
Pharmacology. Drug treatments
Shrews
Suncus
Vomiting - chemically induced
Vomiting - etiology
Vomiting - prevention & control
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Summary:Emetic and antiemetic effects of morphine were investigated in Suncus murinus. Subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 μg) of morphine failed to cause emesis. However, pretreatment with morphine (s.c.) prevented the emesis induced by nicotine (10 mg/kg, i.p.), copper sulfate (40 mg/kg, p.o.), cisplatin(20 mg/kg, i.p.) and motion stimulus. These results suggest that morphine has only antiemetic potency and may block a common mechanism for the emetic reflex of suncus, because the antiemetic effects of the drug were exerted irrespective of the stimulus.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.20.739