Isolation and Antihyperglycemic Activity of Bakuchiol from Otholobium pubescens (Fabaceae), a Peruvian Medicinal Plant Used for the Treatment of Diabetes

The known compound bakuchiol (1) was isolated from an extract of Otholobium pubescens (Fabaceae) by bioassay-guided fractionation using the db/db mouse model for tyep 2 diabets. Oral administration of 1 reduced blood glucose levels in a dose-dependent fashion in db/db mice and did not display a hypo...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1999/10/15, Vol.22(10), pp.1137-1140
Main Authors: KRENISKY, Joann M., LUO, Jian, REED, Michael J., CARNEY, John R.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
antihyperglycemic activity
bakuchiol
Biological and medical sciences
Diabetes Mellitus, Type 2 - chemically induced
Diabetes Mellitus, Type 2 - drug therapy
Dose-Response Relationship, Drug
Fabaceae
General and cellular metabolism. Vitamins
General pharmacology
Glucose - metabolism
Hypoglycemic Agents - therapeutic use
Male
Medical sciences
Mice
Mice, Inbred C57BL
Otholobium pubescens
Peru
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - therapeutic use
Plants, Medicinal - chemistry
Psoralea pubescens
Rats
Rosales - chemistry
Streptozocin
Time Factors
type 2 diabetes, antidiabetic activity
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Summary:The known compound bakuchiol (1) was isolated from an extract of Otholobium pubescens (Fabaceae) by bioassay-guided fractionation using the db/db mouse model for tyep 2 diabets. Oral administration of 1 reduced blood glucose levels in a dose-dependent fashion in db/db mice and did not display a hypoglycemic effect when tested in lean mice at 250 mg/kg q.d. Compound 1 was further evaluated in a new rodent model for type 2 diabetes, the fat-fed, streptozotocin (STZ)-treated rat. In this model, an oral dose of 1 at 150 mg/kg q.d. significantly lowered plasma glucose and triglyceride levels.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.22.1137