Involvement of Serotonin in Zimelidine-Induced Hyperglycemia in Mice

Effects of a selective serotonin reuptake inhibitor, zimelidine, on plasma glucose was studied in mice. Zimelidine dose-dependently induced hyperglycemia, although it did not change insulin levels. To determine the involvement of the serotonergic system in zimelidine-induced hyperglycemia, effects o...

Full description

Saved in:
Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1999/11/15, Vol.22(11), pp.1240-1241
Main Authors: SUGIMOTO, Yumi, INOUE, Kiyo, YAMADA, Jun
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - metabolism
Dose-Response Relationship, Drug
Drug toxicity and drugs side effects treatment
Fenclonine - pharmacology
hyperglycemia
Hyperglycemia - chemically induced
insulin
Insulin - blood
Male
Medical sciences
Mice
mouse
p-chlorophenylalanine(pCPA)
Pharmacology. Drug treatments
Serotonin - physiology
Serotonin Agents - pharmacology
Serotonin Uptake Inhibitors - pharmacology
Time Factors
Toxicity: nervous system and muscle
Zimeldine - pharmacology
zimelidine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Effects of a selective serotonin reuptake inhibitor, zimelidine, on plasma glucose was studied in mice. Zimelidine dose-dependently induced hyperglycemia, although it did not change insulin levels. To determine the involvement of the serotonergic system in zimelidine-induced hyperglycemia, effects of the 5-HT depleter p-chlorophenylalanine(pCPA) were examined. pCPA significantly reduced zimelidine-induced hyperglycemia. This suggests that zimelidine-induced hyperglycemia is mediated by the serotonergic system through its 5-HT reup-take inhibition.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.22.1240