Effects of Midodrine on Chlorpromazine-Induced Orthostatic Hypotension in Rabbits

Orthostatic hypotension was produced in urethane-anesthetized rabbit by a combination of chlorpromazine (0.1 mg/kg, i.v.) and 45° head-up tilt. The effect of midodrine (1 and 3 mg/kg, i.d.) was investigated in comparison with amezinium (10 and 30 mg/kg, i.d.), etilefrine (10 and 30 mg/kg, i.d.) and...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2000-12, Vol.23 (12), p.1445
Main Authors: KURIHARA, Junichi, TAKATA, Yoshinobu, SUZUKI, Shigeo, OKUBO, Yoko, KATO, Hitoshi
Format: Article
Language:English
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Summary:Orthostatic hypotension was produced in urethane-anesthetized rabbit by a combination of chlorpromazine (0.1 mg/kg, i.v.) and 45° head-up tilt. The effect of midodrine (1 and 3 mg/kg, i.d.) was investigated in comparison with amezinium (10 and 30 mg/kg, i.d.), etilefrine (10 and 30 mg/kg, i.d.) and droxidopa (30 and 100 mg/kg, i.d.). The higher doses of each drug significantly mitigated the chlorpromazine-induced orthostatic hypotension, while none of the lower doses caused a significant effect. The effect of midodrine developed most rapidly; a significant effect was observed 25 min after administration. The order of onset time was midodrine
ISSN:0918-6158
1347-5215