Pharmacokinetic Differences between Lansoprazole Enantiomers and Contribution of Cytochrome P450 Isoforms to Enantioselective Metabolism of Lansoprazole in Dogs

The purpose of this study was to evaluate the pharmacokinetics of lansoprazole enantiomers and contribution of cytochrome P450 enzymes to enantioselective metabolism in dogs. The mean Cmax and area under the curve (AUC) values of (+)-lansoprazole were 4—5 times greater than those of (−)-lansoprazole...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2001, Vol.24(3), pp.274-277
Main Authors: MASA, Kengo, HAMADA, Akinobu, ARIMORI, Kazuhiko, FUJII, Junko, NAKANO, Masahiro
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles
Animals
Area Under Curve
Biological and medical sciences
Biotransformation
Cytochrome P-450 Enzyme System - metabolism
Digestive system
Dogs
Drug Interactions
enantiomer
enantioselectivity
Enzyme Inhibitors - pharmacokinetics
Enzyme Inhibitors - pharmacology
Half-Life
In Vitro Techniques
Isoenzymes - metabolism
Lansoprazole
Male
Medical sciences
metabolism
Microsomes, Liver - metabolism
Omeprazole - analogs & derivatives
Omeprazole - pharmacokinetics
Omeprazole - pharmacology
Pharmacology. Drug treatments
Protein Binding
Proton Pump Inhibitors
Stereoisomerism
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Summary:The purpose of this study was to evaluate the pharmacokinetics of lansoprazole enantiomers and contribution of cytochrome P450 enzymes to enantioselective metabolism in dogs. The mean Cmax and area under the curve (AUC) values of (+)-lansoprazole were 4—5 times greater than those of (−)-lansoprazole following oral administration of 30-mg racemic lansoprazole to dogs. The CLtot/F values of (+)-lansoprazole were significantly smaller than those of (−)-lansoprazole (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.24.274